Cancer Immunogene Therapy
スポンサーリンク
概要
- 論文の詳細を見る
The identification and characterization of tumor antigens as well as the expansion of knowledge on the cellular and molecular mechanisms of antigen recognition by the immune system have raised the possibility of using immunotherapy to treat certain tumors. Information on these mechanisms has been obtained in three crucial areas : 1) the role of cytokines in the regulation of the immune response; 2) the molecular characterization of tumor antigens in both mouse and human tumors; 3) the molecular mechanisms of T cell activation and antigen presentation. Such information has provided new insight into tumor immunology and immunotherapy. Furthermore, recombinant DNA technology allows for modification of the genome of mammalian cells for therapeutic purposes in several diseases. Several novel strategies have been developed to derive genetically modified tumor cells and use them as cellular vaccines to induce antitumor immunity in animal tumor models. This combined modality of genetically modified tumor cells and immunotherapy has been termed the immunogene therapy of tumors. Crucial to this approach has been the ability to transfer into normal or neoplastic cells, genes known to increase the immunogenicity of cells, which subsequently can be used to augment immune reactions in tumor-bearing mice or cancer patients. While there has been success in inducing antitumor immunity in some tumor models, there are difficulties and limitations in the application of these gene-modified tumor cells for the treatment of preexisting tumors. In this review, recent progress in cancer immunogene therapy is discussed.
- 新潟大学の論文
著者
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Gejyo Fumitake
新潟大学 医歯学総合研究科第二内科
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Gejyo F
Division Of Clinical Nephrology And Rheumatology Graduate School Of Medical And Dental Sciences Niig
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Gejyo Fumitake
Department Of Medicine Iigata University School Of Medicine
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Gejyo Fumitake
Department Of Clinical And Laboratory Medicine Fukui Medical University
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Yoshizawa H
Department Of Internal Medicine (ii) Niigata University School Ofmedicine
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Yoshizawa Hirohisa
Department Of Second Internal Medicine Niigata University School Of Medicine
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Hirohisa YOSHIZAWA
Department of Internal Medicine (II), Niigata University School ofMedicine
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Fumitake GEJYO
Department of Internal Medicine (II), Niigata University Schoolof Medicine
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Fumitake Gejyo
Department Of Internal Medicine (ii) Niigata University School Ofmedicine
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Gejyo Fumitake
The Division Of Clinical Nephrology And Rheumatology Niigata University Graduate School Of Medical And Dental Sciences
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YOSHIZAWA Hirohisa
Department of Internal Medicine (II), Niigata University School ofMedicine
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