Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases
スポンサーリンク
概要
- 論文の詳細を見る
Streptococcal toxic shock-like syndrome (TSLS) is one of the fulminant types of toxic infectious diseases caused by Streptococcus pyogenes. Although there are several candidates as the virulence factors including M protein, little is known why TSLS is caused by only some of S. pyogenes strains but not by others. In this study, we compared the cytokine inducing activity in mice between S. pyogenes M-3 type strains derived from TSLS and non-TSLS cases. After infection into mice, TSLS-derived strains persisted longer in the blood than non-TSLS-derived strains. Moreover, TSLS-derived strains were highly capable of inducing proinflammatory cytokines both in vivo and in vitro. TSLS-derived strains also showed a higher ability to produce streptolysin O (SLO). These findings suggest that SLO plays a role as a possible virulence factor accounting for the shock induction in the infected host.
- 新潟大学の論文
著者
-
Gejyo Fumitake
Department Of Clinical And Laboratory Medicine Fukui Medical University
-
Kawamura Ikuo
Department Of Bacteriology Niigata University School Of Medicine
-
Tsutsui Nanako
Department Of Internal Medicine Ii School Of Medicine Niigata University:niigata City General Hospit
-
Mitsuyama Masao
Department Of Microbiology Kyoto University Graduate School Of Medicine
-
Mitsuyama Masao
Department Of Bacteriology Niigata University Of School Of Medicine
-
Gejyo Fumitake
Department Of Internal Medicine Ii School Of Medicine Niigata University
関連論文
- Three-dimensional Analysis of Nephrogenesis in the Neonatal Rat Kidney : Light and Scanning Electron Microscopic Studies
- C-terminus SDEL of BMZ Olfactomedin-related Protein is a Golgi Retention Signal in Glomerular Podocytes
- Human voltage-dependent anion selective channel 1 is a target antigen for antiglomerular endothelial cell antibody in mixed connective tissue disease
- Determination of Optimal Blood Pressure for Patients with IgA Nephropathy Based on Renal Histology
- Effectiveness of Oseltamivir Treatment among Children with Influenza A or B Virus Infections during Four Successive Winters in Niigata City, Japan
- Seeligeriolysin O, a protein toxin of Listeria seeligeri, stimulates macrophage cytokine production via Toll-like receptors in a profile different from that induced by other bacterial ligands
- Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease
- Molecular Epidemiology of Intrafamilial Mycobacterium tuberculosis Infections in Niigata, Japan
- The methylguanidine-to-creatinine ratio, serum NOx concentrations, and vascular disease in nondiabetic hemodialysis patients
- Ultrastructural characteristics of diabetic nephropathy
- Effectiveness of omeprazole for the treatment of upper gastrointestinal lesions in rheumatoid arthritis patients
- Systemic sclerosis in two second cousins : a case report
- Correlation between the Presence of Virulence-Associated Genes as Determined by PCR and Actual Virulence to Mice in Various Strains of Listeria Spp.
- Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Thrombocytopenia Caused by Cytomegalovirus Infection In a Young Immunocompetent Woman
- The role of Kupffer cells and regulation of neutrophil migration into the liver by macrophage inflammatory protein-2 in primary listeriosis in mice
- Echocardiographic Evaluation of Cardiac Valvular Abnormalities in Adults with Down's Syndrome
- Anti-cachectic Effect of FK317, a Novel Anti-cancer Agent, in Colon26 and LX-1 Models in Mice
- FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice
- Different Effects of FK317 on Multidrug-resistant Tumor in vivo and in vitro
- Cytotoxic Mechanisms of FK317, a New Class of Bioreductive Agent with Potent Antitumor Activity
- Human parvovirus B19 infection mimicking systemic lupus erythematosus
- Serum Levels of Soluble Interleukin-2 Receptor in Patients with Various Renal Diseases
- Involvement of Reactive Oxygen Intermediate in the Enhanced Expression of Virulence-Associated Genes of Listeria monocytogenes inside Activated Macrophages
- DEPTH-LIMITED OSCILLATORY BOUNDARY LAYERS ON A ROUGH BOTTOM
- Developmental Changes in the Structure of the Rat Fetal Lung, with Special Reference to the Airway Smooth Muscle and Vasculature
- Cancer Immunogene Therapy
- Stimulation of Choleresis by Insulin-Like Growth Factor-l in Rats
- Protective Effect of Administration of Skim Milk on Exogenous and Endogenous Infection in Mice
- Mycobacterial Mammalian Cell Entry Protein 1A (Mce1A)-Mediated Adherence Enhances the Chemokine Production by A549 Alveolar Epithelial Cells
- Molecular Epidemiology of Intrafamilial Mycobacterium tuberculosisInfections in Niigata Japan
- Overgrowth and translocation of Escherichia coli from intestine during prolonged enteral feeding in rats
- Distinct cytokine-inducing ability of Streptococcus pyogenes strains isolated from toxic shock-like syndrome cases
- Pulmonary Function Analysis of Japanese Athletes : Possibly Even More Asthmatics in the Field
- Antitumor Effects of Droloxifene, a New Antiestrogen Drug, against 7, 12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats.
- The Estrogenic and Antiestrogenic Activities of Droloxifene in Human Breast Cancers.
- Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Thrombocytopenia Caused by Cytomegalovirus Infection In a Young Immunocompetent Woman