<Original article>The Preventive Effect of β-blockers, Carvedilol and Metoprolol, on Mental Stress-induced Changes in Cardiovascular Functions by a Color Word Conflict Test
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概要
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Experimental mental stress by a computerized color word conflict test was developed. The effects of a single oral administration of two different β-blockers, carvedilol (a vasodilating β-/α_1-blocker, 20 mg) and metoprolol (a β_1-selective blocker, 20 mg), on a color word conflict test (mental stress)-induced increase in heart rate and systolic blood pressure were investigated in 108 healthy volunteers, 21-24 years of age, by double blind protocol. At rest carvedilol and metoprolol gradually reduced the heart rate, and slightly lowered systolic and diastolic blood pressure. The mental stress by the color word conflict test significantly increased the heart rate and systolic blood pressure by a respective 3.1±0.6/min and 2.0±0.9mmHg. Carvedilol completely inhibited the mental stress-induced increases in both systolic blood pressure and heart rate 3 h after administration, and metoprolol significantly blocked the increase in systolic blood pressure. These findings indicated that β-blockers effectively prevent mental stress-induced changes in cardiovascular functions.
- 新潟大学の論文
著者
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Watanabe Yasuo
Division of cardiology, Department of Medicine, Nihon University school of Medicine
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GEJYO Fumitake
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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HIGUCHI Hiroshi
Division of Pharmacology, Department of Molecular Genetics and Signal Transduction Research, Course
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OKADA Masayoshi
Division of Pharmacology, Department of Molecular Genetics and Signal Transduction Research, Course
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Okada Masayoshi
Division Of Pharmacology Department Of Molecular Genetics And Signal Transduction Research Course Fo
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Okada Masayoshi
Division Of Pharmacology Department Of Molecular Genetics And Signal Transduction Research Course Fo
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TSURUMAKI Tatsuru
Division of Pharmacology, Department of Molecular Genetics and Signal Transduction Research, Course
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Tsurumaki Tatsuru
Division Of Pharmacology Department Of Molecular Genetics And Signal Transduction Research Course Fo
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Higuchi H
Niigata Univ. Graduate School Of Medical And Dental Sci. Niigata Jpn
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Higuchi Hiroshi
Division Of Neuroeurgery Department Of Brain Diseases Tohoku University School Of Medicine
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Higuchi Hiroshi
Division Of Pharmacology Department Of Molecular Genetics And Signal Transduction Research Course Fo
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Gejyo Fumitake
Department Of Medicine Iigata University School Of Medicine
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Gejyo Fumitake
Division Of Clinical Nephrology And Intensive Care Medicine Niigata University Graduate School Of Me
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Watanabe Yasuo
Division Of Pharmacology Department Of Molecular Genetics And Signal Transduction Research Course Fo
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Gejyo Fumitake
Division Of Clinical Nephrology And Rheumatology Niigata University Graduate School Of Medical And D
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Gejyo Fumitake
Division Of Clinical Infection Control And Prevention Niigata University Graduate School Of Medical
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Higuchi Hiroshi
Division of Otolaryngology, Graduate School of Medical and Dental Sciences, Niigata University
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