Reduced Fibrinolytic Activity in Bronchoalveolar Lavage Fluids is not Related to Alveolar Macrophages in the Fibrosis of Interstitial Pneumonia : An Analysis of Bronchoalveolar Lavage Fluids

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概要

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• Reduced fibrinolytic activity in the alveolar space of patients with interstitial pneumonia (IP) is considered the key factor in the development of pulmonary fibrosis. However, the origin of this fibrinolytic activity and its relationship to the fibrosis in IP is still unclear. Levels of the urokinase-type plasminogen activator (u-PA) and plasminogen activator inhibitor 1 (PAI-1) antigen were measured in bronchoalveolar lavage fluids (BALF) obtained from patients with IP, and the data were compared between the two groups (fibrosing group and non-fibrosing group) based mainly on honeycomb formation revealed by pulmonary high-resolution computed tomography (HRCT) and partially on lung histology. In addition, the cell surface plasmin generation of various alveolar macrophages (AM) and its correlation with the u-PA/PAI-1 levels in each of the two groups were studied. The u-PA level was significantly lower in BALF from IP patients than from sarcoidosis patients with no interstitial shadows on HRCT used as the contols. Although u-PA and PAI-1 levels did not differ between the fibrosing and the non-fibrosing group, the macrophage count and the percentage of macrophages in BALF were significantly greater in the fibrosing group. The major regulatory cytokines, interleukin 1-β and transforming growth factor-β, however, did not affect cell surface plasmin generation by AM, indicating that the AM-related fibrinolytic activity was constant. These results indicate that the decreased fibrinolytic activity in BALF is not related to AM although it is associated with the fibrosis of IP. We speculate that other cells such as alveolar epithelial cells contribute to the fibrosis although further clinical studies will be required.

• 新潟大学の論文

著者

• Hasegawa Go

  Department Of General Medicine Niigata University Medical And Dental Hospital

• HASEGAWA Takashi

  Department of General Medicine, Niigata University Medical and Dental Hospital

• KOYA Toshiyuki

  Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences

• GEJYO Fumitake

  Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences

• SUZUKI Eiichi

  Department of General Medicine, Niigata University Medical and Dental Hospital

• Hasegawa Takashi

  新潟大学 医歯学総合研究科呼吸器内科分野

• Gejyo F

  Division Of Respiratory Medicine Department Of Homeostatic Regulation And Development Course In Biol

• TAKADA Toshinori

  Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Bi

• TSUKADA Hiroki

  Division of Clinical Infection Control and Prevention, Niigata University Graduate School of Medical

• Narita Jun-ichi

  Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences

• Terada Masaki

  Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences

• Hasegawa Takashi

  Department Of General Medicine Niigata University Medical And Dental Hospital

• Tsukada Hiroki

  Division Of Clinical Nephrology Respiratory Medicine And Infection Control And Prevention Niigata Un

• Tsukada Hiroki

  Division Of Clinical Infection Control And Prevention Niigata University Graduate School Of Medical

• SAITO Yasuharu

  Department of Physics, Graduate School of Science, Tohoku University

• Moriyama Hiroshi

  Division Of Respiratory Medicine Graduate School Of Medical And Dental Sciences Niigata University

• GONDAIRA Fumio

  Division of Bacteriology, Department of Infectious Disease Control and International Medicine.

• Yamaguchi Seigo

  Division Of Respiratory Medicine Graduate School Of Medical And Dental Sciences Niigata University:d

• Saito Yasuharu

  Department Of Respiratory Medicine Nishi-niigata Chuo National Hospital

• Gejyo Fumitake

  Department Of Medicine Iigata University School Of Medicine

• Terada Masaki

  Division Of Respiratory Medicine Graduate School Of Medical And Dental Sciences Niigata University

• Gejyo Fumitake

  Division Of Clinical Nephrology And Intensive Care Medicine Niigata University Graduate School Of Me

• Takada Toshinori

  Division Of Respiratory Medicine Department Of Homeostatic Regulation And Development Course In Biol

• Koya Toshiyuki

  Division Of Respiratory Medicine Department Of Homeostatic Regulation And Development Course In Biol

• Koya Toshiyuki

  新潟大学 医歯学総合研究科生体機能調節医学専攻呼吸器内科学

• Narita Jun-ichi

  Division Of Respiratory Medicine Graduate School Of Medical And Dental Sciences Niigata University

• Saito Yasuharu

  Department Of Medicine Shiga University Of Medical Science

• Gejyo Fumitake

  The Division Of Clinical Nephrology And Rheumatology Niigata University Graduate School Of Medical A

• Suzuki Eiichi

  Department Of Chemistry & Bioengineering Iwate University

• Gejyo Fumitake

  Division Of Clinical Nephrology And Rheumatology Niigata University Graduate School Of Medical And D

• Gejyo Fumitake

  Division Of Clinical Infection Control And Prevention Niigata University Graduate School Of Medical

• Moriyama Hiroshi

  Division Of Cardiology South-1 Hospital

• Suzuki Eiichi

  Department Of Chemical Engineering Iwate University

• Hasegawa Takashi

  Department Of Biology Division Of Natural Science International Christian University

• Suzuki Eiichi

  Department Of Applied Chemistry Tokyo Institute Of Technology

• Gejyo Fumitake

  Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University

• Saito Yasuharu

  Department of Endoscopy, Shiga University of Medical Science

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