Upper Lobe-Dominant Pulmonary Fibrosis Showing Deposits of Hard Metal Component in the Fibrotic Lesions
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概要
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We present a 54-year-old man employed in the field of hard metal manufacturing who complained of progressive dyspnea and weight loss. His chest radiograph showed bilateral fibrosis predominantly distributed in the upper lobes with bilateral pleural effusions, and a strong reduction in lung volume. Lung histopathology showed apical cap-like fibrosis but no giant cell interstitial pneumonia. Electron probe microanalysis detected tungsten deposits in the fibrotic region: we therefore considered this to be a case of hard metal disease. Hard metal disease should be considered as one possibility in the differential diagnosis of upper lobe-dominant pulmonary fibrosis.
著者
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SUZUKI Eiichi
Department of General Medicine, Niigata University Medical and Dental Hospital
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Hizawa Nobuyuki
Department Of Pulmonary Medicine Graduate School Of Comprehensive Human Sciences University Of Tsuku
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ISHII Yukio
Department of Respiratory Medicine, University of Tsukuba
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Kobayashi Masayoshi
Epma Laboratory Niigata University Center For Instrumental Analysis
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Ishii Yukio
Department Of Respiratory Medicine Doctoral Programs In Medical Sciences Graduate School Of Comprehe
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Terada Masaki
Division Of Respiratory Medicine Graduate School Of Medical And Dental Sciences Niigata University
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Kaneko Yoshiko
Department Of Molecular Pharmacology Kitasato Universty School Of Pharmaceutical Sciences
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Kawabata Yoshinori
Department Of Thoracic Surgery And Pathology Saitama Cardiovascular And Respiratory Center
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Moriyama Hiroshi
Division Of Cardiology South-1 Hospital
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Suzuki Eiichi
Department Of Applied Chemistry Tokyo Institute Of Technology
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Moriyama Hiroshi
Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Kikuchi Norihiro
Department of Respiratory Medicine, University of Tsukuba
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Watanabe Kouichi
EPMA Laboratory, Center of Instrumental Analysis, Niigata University
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Ishii Yukio
Department of Pulmonary Medicine, Institute of Clinical Medicine, University of Tsukuba
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Kikuchi Norihiro
Department of Pulmonary Medicine, Institute of Clinical Medicine, University of Tsukuba
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