Anti-Ku Antibody-Positive Scleroderma-Dermatomyositis Overlap Syndrome Developing Greves' Disease and Immune Thrombocytopenic Purpura

概要

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Graves disease (GD) has been reported to be frequently complicated with other autoimmune diseases. However, it is rarely complicated with scleroderma-polymyositis overlap syndrome. Recently, we encountered a 35-year-old woman who developed GD and immune thrombocytopenic purpura during follow-up observation of scleroderma-dermatomyositis overlap syndrome. Platelet counts recovered after high-dose γ-globulin therapy and bolus methylprednisolone therapy. The present case is the first report of a combination of scleroderma, dermatomyositis, GD, and immune thrombocytopenic purpura. The patient was anti-Ku antibody-positive and had relatively low natural killer T cell counts, both of which might contribute to the complication of multiple autoimmune diseases.(Internal Medicine 41: 1199-1203, 2002)
社団法人日本内科学会の論文
2002-12-01