Induction of Heme Oxygenase-1 Inhibits Monocyte Chemoattractant Protein-1 mRNA Expression in U937 Cells
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概要
- 論文の詳細を見る
Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential cytoprotective effects. Monocyte activation/migration mediated by monocyte chemoattractant protein-1 (MCP-1) is one of the earliest and important events in the pathogenesis of atherosclerosis. We examined the effect of HO-1 on the production of lysophosphatidylcholine (Lyso-PC)-induced MCP-1 in the human promonocytic cell line U937. Increased HO-1 induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. These results suggest that HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 production.
- 社団法人 日本薬理学会の論文
- 2006-02-20
著者
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YAMAMOTO Hideya
Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University
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KOHNO Nobuoki
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
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Yoshizumi Masao
Division Of Cardiology Cardiovascular Center Akane Foundation Tsuchiya General Hospital
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Shimizu Yoshito
Mazda Hospital
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Shokawa Tomoki
Department of Molecular and Internal Medicine, graduate School of Biomedical Sciences, Hiroshima Uni
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YOSHIZUMI Masao
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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Yamamoto Hideya
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Hiroshima University
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Imazu Michinori
Departments of Internal Medicine II
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Toyofuku Mamoru
Department Of Cardiology Tsuchiya Genaral Hospital
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Imazu Michinori
Division Of Cardiology Tsuchiya General Hospital
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Imazu Michinori
Department Of Medicine Ajina Tsuchiya Hospital
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
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Yamamoto Hideya
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
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Shokawa Tomoki
Department Of Cardiovascular Medicine Hiroshima University
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Yamamoto Hideya
Hiroshima - CT Angiography Research Project (H-CARP) Group
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Kohno Nobuoki
Department Of Internal Medicine Hiroshima University Graduate School Of Medicine
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Kohno Nobuoki
Second Department Of Internal Medicine Hiroshima University School Of Medicine
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Yoshizumi Masao
Department Of Cardiovascular Physiology And Medicine
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Shokawa Tomoki
Advanced Emergency And Critical Care Center Hiroshima University Hospirtal
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OMURA Shinji
Department of Biomedical Chemistry, Graduate School of Biomedical Sciences, Hiroshima University
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SHIMIZU Yoshito
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni
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Yoshimura Mitsuisa
From The Division Of Cardiology Hiroshima City Hospital
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Omura Shinji
Department Of Biomedical Chemistry Graduate School Of Biomedical Sciences Hiroshima University
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Yamamoto Hideya
Department Of Molecular And Internal Medicine Hiroshima University
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Hiroshima University
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Kohno Nobuoki
Department Of Molecular And Internal Medicine Division Of Clinical Medical Science Programs For Appl
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Imazu Michinori
Second Department Of Internal Medicine Hiroshima University School Of Medicine
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Yoshizumi Masao
Cardiovascular Center Tsuchiya General Hospital
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Yamamoto Hideya
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Yamamoto Hideya
Department Of Molecular And Internal Medicine Graduate School Of Biomedical Sciences Hiroshima Unive
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Yamamoto Hideya
Department Of Molecular And Internal Medicine Hiroshima University Graduate School Of Biomedical Sci
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Yoshizumi Masao
Department Of Cardiovascular Phisiology Graduate School Of Medicine Hiroshima University
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Toyofuku Mamoru
Department Of Cardiology Cardiovascular Center Tsuchiya General Hospital
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Imazu Michinori
Department of Cardiology, Akane-kai, Tsuchiya General Hospital
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