Comparison of Effects of Famotidine on Vagally and Field - Electrically Stimulated Acid Secretion in the Isolated Mouse Whole Stomach
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概要
- 論文の詳細を見る
Effects of famotidine on neuronally evoked acid secretion were investigated by means of vagal (at the lower esophagus level) and field-electrical stimulation (around the stomach) in the isolated mouse whole stomach preparation. Each of the electrical stimulations caused a frequency-dependent (1 to 20 Hz) increase in acid output, and the secretory response was abolished by tetrodotoxin or atropine. In the case of field stimulation, the acid secretion was not completely inhibited by hexamethonium. When 10 Hz frequency was applied with either vagal or field-electrical stimulation, the acid secretion was only partly inhibited by famotidine at doses of up to 30 μM. In contrast, the acid response to 2 Hz stimulation was almost completely inhibited by 1 μM famotidine. In the presence of neostigmine (30 nM), the 2 Hz vagally stimulated acid secretion became partly resistant to the effect of famotidine (10 μM). These results suggest that both vagally and field-electrically stimulated acid secretions have essentially the same characteristics and that the secretory mechanism through histamine release is exclusively dominant with weak stimulation, while the cholinergic mechanism on parietal cells is sufficient for reaching the maximal secretory response with strong stimulation.
- 社団法人 日本薬理学会の論文
- 1995-11-01
著者
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Yano S
Ciba‐geigy Japan Ltd. Takarazuka Jpn
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Yano Shingo
Laboratory Of Molecular Pharmacology & Pharmacotherapeutics Graduate School Of Pharmaceutical Sc
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Yamamoto Masayuki
Laboratory for radar atmospheric sciences, RISH, Kyoto University
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WATANABE Kazuo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Facul
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Yamamoto M
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Department Of Drug Evaluation And Toxicological Sciences Faculty
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Watanabe Kazuo
Laboratory Of Applied Botany Faculty Of Agriculture Kyoto University
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Watanabe K
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Watanabe Kazuo
Department Of Drug Evaluation And Toxicological Sciences Chiba University
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YANO Shingo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University
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