Stimulatory Effects of Centrally Injected Nitric Oxide Donors on Gastric Acid Secretion in Anesthetized Rats
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概要
- 論文の詳細を見る
The effects of centrally injected nitric oxide (NO) donors on gastric acid secretion were investigated in continuously perfused stomach of anesthetized rats. The lateral cerebroventricular (LV) injection of NOC5 (30 – 100 μg) and NOC12 (10 – 100 μg) dose-dependently stimulated gastric acid secretion. The LV injection of NOC18 (30 μg) also stimulated gastric acid secretion. The other type of NO donor, sodium nitroprusside (3 – 30 μg, LV), also dose-dependently stimulated gastric acid secretion. The effect of NOC5 at 100 μg was blocked by carboxy-PTIO, an NO scavenger, and by cervical vagotomy. Furthermore, NOC12 (30, 100 μg) dose-dependently stimulated gastric acid secretion in pylorus-ligated conscious rats. These results suggest that centrally injected NO donors stimulate gastric acid secretion in both conscious and anesthetized rats through vagus activation.
- 社団法人 日本薬理学会の論文
- 2002-06-01
著者
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Sekine T
Graduate School Of Pharmaceutical Sciences Chiba University
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Horie Syunji
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Josai International University
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Horie S
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Horie Syunji
Laboratory Of Chemical Pharmacology Chiba University
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WATANABE Kazuo
Laboratory of Chemical Pharmacology, Department of Drug Evaluation and Toxicological Sciences, Facul
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Horie S
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Tsuchiya Shizuko
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University
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Tsuchiya Shizuko
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Watanabe Kazuo
Hokkaido Pharmaceutical University School Of Pharmacy
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Tsuchiya Shizuko
Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie
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Tsuchiya Shizuko
Dept Of Mol. Pharmacol. & Pharmacother Grad. Sch. Pharm. Sci. Chiba Univ.
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Watanabe Kazuo
Laboratory Of Applied Botany Faculty Of Agriculture Kyoto University
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Watanabe Kazuo
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Tsuchiya Shizuko
Laboratory Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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