Synthesis and Pharmacological Activity of O-(5-Isoxazolyl)-L-serine

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概要

• 論文の詳細を見る

• A novel isoxazole derivative, O-(5-isoxazolyl)-L-serine (OIS, 1), was synthesized by a Mitsunobu reaction of isoxazolin-5-one (4) with N-Boc-L-serine tert-butyl ester (5) and subseaquent deprotection of the coupling product. Its structure was elucidated by sectroscopic analyses. The pharmacological activity of 1 was also examined with cloned glutamate receptors and transporters using a Xenopus oocyte-expressing system showing substrate activity on an excitatory amino acid carrier 1 (EAAC 1) as a glutamate transporter.

• 社団法人日本薬学会の論文
• 2000-02-01

著者

• Ishikawa Tsutomu

  Faculty of Pharmaceutical Sciences, Chiba University

• Sekine T

  Graduate School Of Pharmaceutical Sciences Chiba University

• Sekine Toshikazu

  タイ

• Sekine Toshikazu

  Faculty Of Engineering Gifu University

• Sekine Toshikazu

  Faculty Of Pharmaceutical Sciences Chiba University

• IKEGAMI Fumio

  Faculty of Pharmaceutical Sciences, Chiba University

• YAMAMOTO Akemi

  Faculty of Pharmaceutical Sciences, Chiba University

• KUSAMAE-EGUCHI Kuniko

  Nihon University College of Pharmacy

• KUSAMA Tadashi

  Nihon University College of Pharmacy

• WATANABE Kazuko

  Nihon University College of Pharmacy

• KUSAMA-EGUCHI Kuniko

  Laboratory of Biology, College of Pharmacy, Nihon University

• IKEGAMI Fumio

  Center for Environment, Health and Field Sciences, Chiba University

• Kusama T

  Laboratory Of Physiology And Anatomy College Of Pharmacy Nihon University

• Kusama Tadashi

  School Of Pharmacy Nihon Univ.

• Kusama Tadashi

  Department Of Physiology And Anatomy Nihon University College Of Pharmacy

• Ishikawa Tsutomu

  Faculty Of Pharmaceutical Sciences Chiba University

• Ikegami F

  Center For Environment Health And Field Sciences Chiba University

• Ikegami Fumio

  Faculty Of Engineering Takushoku University

• Tsuchiya Shizuko

  Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences Chiba University

• Tsuchiya Shizuko

  Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie

• Kusama‐eguchi Kuniko

  Nihon Univ. Chiba Jpn

• Tsuchiya Shizuko

  Department Of Molecular Pharmacology And Pharmacotherapeutics Graduate School Of Pharmaceutical Scie

• Tsuchiya Shizuko

  Dept Of Mol. Pharmacol. & Pharmacother Grad. Sch. Pharm. Sci. Chiba Univ.

• Watanabe Kazuko

  Laboratory Of Molecular Cell Biology College Of Pharmacy Nihon University

• Yamamoto Akemi

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamamoto Akemi

  Faculty Of Agriculture Niigata University

• SEKINE Toshikazu

  Faculty Engineering Gifu University Japan

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