N.OMEGA.-hydroxy-L-arginine, an intermediate in nitric oxide synthesis, is more potent than L-arginine for endothelium-dependent vascular relaxation.
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概要
- 論文の詳細を見る
L-Arginine (Arg) and related amino acids are involved in the pathophysiology of cardiovascular disease. Endothelium-derived relaxing factor, nitric oxide (NO), is generated by vascular endothelial cells from Arg. In this study, high purity N<SUP>ω</SUP>-hydroxy-L-arginine (OHArg), an intermediate in the pathway generating NO, was synthesized, and the effects of Arg and OHArg on endothelium-dependent vascular relaxation were examined.<BR>OHArg caused a significant relaxation of endothelium-intact rat aortic rings that had been contracted by norepinephrine. OHArg was more potent than Arg at aortic relaxation (OHArg<SUB>ED80</SUB> =10<SUP>-7.4</SUP>M versus Arg<SUB>ED80</SUB> 10<SUP>-5.5</SUP>M). Neither OHArg nor Arg relaxed the endothelium-denuded or NO synthase-inhibited aortic rings. These results suggest that OHArg is more potent than Arg at inducing vascular relaxation that is endothelium-dependent and NO synthase-dependent. OHArg may be useful in the treatment of hypertension and in the prevention of atherosclerosis.
- 北関東医学会の論文
著者
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NAKAMURA Tetsuya
The Second Department of Internal Medicine, Gunma University School of Medicine
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SATO Kunio
the Second Department of Internal Medicine, Gunma University School of Medicine
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SAKAMOTO Hironosuke
the Second Department of Internal Medicine, Gunma University School of Medicine
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Sakamoto Hironosuke
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Ishikawa Tsutomu
Faculty of Pharmaceutical Sciences, Chiba University
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Ishikawa Tsutomu
Faculty Of Pharmaceutical Sciences Chiba University
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Sakamaki Tetsuo
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Nagai Ryozo
The Second Department Of Internal Medicine Gunma University
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Ikeno Masako
Faculty of Pharmaceutical Sciences, Chiba University
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