Flow-Mediated Vasodilation of a Conduit Artery in Relation to Downstream Peripheral Tissue Blood Flow During Reactive Hyperemia in Humans

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概要

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• Arterial conduit vessels dilate in response to increased blood flow stimuli. Our objective was to determine precisely how a change in large arterial diameter results in a change in peripheral tissue blood flow. Using high-resolution ultrasound Doppler echography, we measured the diameter of the right femoral artery at rest, during reactive hyperemia, and after administration of 2.5 mg of sublingual isosorbide dinitrate in 10 healthy young men. Reactive hyperemia was induced by distal circulatory arrest followed by reperfusion of the leg ipsilateral (right) or contralateral (left) to the side of arterial diameter measurements. Femoral arterial blood flow was calculated by simultaneous measurement of femoral arterial diameter and blood velocity. The change in skin blood flow was also analyzed simultaneously by laser Doppler flowmetry. Reactive hyperemia induced a 2-fold increase in femoral arterial blood velocity 30 sec after cuff release. During this flow augmentation, the femoral artery dilated. The peak of skin blood flow was coincident with the peak of femoral arterial vasodilation. The time required for the return of arterial diameter to baseline was longer than that for blood flow in both the conduit artery and the peripheral skin tissue. Equivalent cuff occlusion and release of the contralateral limb had no effect on ipsilateral arterial diameter. Isosorbide dinitrate induced dilation in all subjects, despite the absence of a significant increase in blood velocity. These results indicate that the human femoral artery dilates in response to increased blood velocity, and that the flow-mediated vasodilation of a large conduit artery is involved in the adjustments of blood flow in the downstream peripheral tissue.

• 社団法人日本循環器学会の論文
• 1997-08-20

著者

• Nakamura Tetsuya

  Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine

• Saito Yuichiro

  高崎健康福祉大学 看護学部看護学科

• Hoshino Jin

  Gunma Aldosterone Study Group

• Nakamura Tetsuya

  群馬大学医学部附属病院 臨床試験部

• NAKAMURA Tetsuya

  Second Department of Internal Medicine, Gunma University School of Medicine

• SAITO Yuichiro

  Second Department of Internal Medicine, Gunma University School of Medicine

• SUMINO Hiroyuki

  Second Department of Internal Medicine, Gunma University School of Medicine

• ONO Zenpei

  Second Department of Internal Medicine, Gunma University School of Medicine

• NAGAI Ryozo

  Second Department of Internal Medicine, Gunma University School of Medicine

• Sakamaki Tetsuo

  Department Of Medical Informatics And Decision Sciences School Of Medicine Gunma University

• Sakamaki Tetsuo

  高崎健康福祉大学 看護学部看護学科

• Ono Zenpei

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Ono Zenpei

  2nd Department Of Internal Medicine Gunma University School Of Medicine

• Ono Zenpei

  The Second Department Of Internal Medicine Gunma University School Of Medicine

• Kanda Tsugiyasu

  高崎健康福祉大学 看護学部看護学科

• Kato Tatsuya

  Second Department of Internal Medicine, Gunma University School of Medicine

• Hoshino Jin

  Second Department of Internal Medicine, Gunma University School of Medicine

• Sakamaki Tetsuo

  Second Department of Internal Medicine, Gunma University School of Medicine

• Kato Tatsuya

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Hoshino Jim

  Second Department Of Internal Medicine Gunma Univercity School Of Medicine

• Sakamaki Tetsuo

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Nagai Ryozo

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Sakamaki Tetsuo

  The Second Department Of Internal Medicine Gunma University School Of Medicine

• Nagai Ryozo

  Second Department Of Internal Medicine And Health Science Gunma University School Of Medicine

• Nakajima Tadashi

  Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An

• Nakamura Tetsuya

  Second Department Of Internal Medicine Gunma University School Of Medicine

• Kanda Tsugiyasu

  The Department Of General Medicine Kanazawa Medical University

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