Dietary Salt Loading Increases Nitric Oxide Synthesis in Transgenic Mice Overexpressing Sodium-Proton Exchanger
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概要
- 論文の詳細を見る
We studied the role of nitric oxide (NO) synthesis in amelioration of blood pressure elevation during dietary salt loading in transgenic mice overexpressing sodium proton exchanger. Systolic blood pressure rose after starting salt loading only in the high-salt group of transgenic mice. However, this elevation of blood pressure was not continued. Urinary excretion of inorganic nitrite and nitrate in the high-salt group of transgenic mice was significantly higher than in the high-salt group of control mice. These results suggest that increased NO synthesis in response to salt loading is one of the anti-hypertensive mechanisms in transgenic mice overexpressing sodium proton exchanger.
- 社団法人 日本薬理学会の論文
- 1999-06-01
著者
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Nakamura Tetsuya
Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine
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Sugiyama Takao
Division of Cardiovascular Diseases, Institute for Adult Diseases Asahi Life Foundation
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Nakamura Tetsuya
群馬大学医学部附属病院 臨床試験部
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KURO-O Makoto
The University of Texas Southwestern Medical Center at Dallas
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NAKAMURA Tetsuya
Second Department of Internal Medicine, Gunma University School of Medicine
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NAGAI Ryozo
Second Department of Internal Medicine, Gunma University School of Medicine
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Kiraku Jun-ichi
Second Department of Internal Medicine, Gunma University School of Medicine
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Sugiyama Takao
朝日生命成人病研究所附属丸の内病院 循環器科
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Sugiyama Takao
The Institute for Adult Diseases Asahi Life Foundation
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Fujii Jun
朝日生命成人病研究所
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Kuroo M
Department Of Pathology University Of Texas Southwestern Medical Center At Dallas
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Fujii Jun
the Institute for Adult Diseases Asahi Life Foundation
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TAKAHASHI Naoyuki
Third Department of Internal Medicine, Tokyo University
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Fujii Jun
The Division Of Cardiovascular Diseases The Institute For Adult Diseases Asahi Life Foundation
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Nakajima Tadashi
Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine
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Kiraku Jun-ichi
Second Department Of Internal Medicine Gunma University School Of Medicine
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Nagai Ryozo
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Takahashi Naoyuki
The Division Of Cardiovascular Diseases The Institute For Adult Diseases Asahi Life Foundation
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Takahashi Nobuhiko
Department Of General Medicine Asahikawa Medical College
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Sugiyama T
The Institute For Adult Diseases Asahi Life Foundation
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Nagai Ryozo
Second Department Of Internal Medicine And Health Science Gunma University School Of Medicine
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Nakajima Tadashi
Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An
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Nakamura Tetsuya
Second Department Of Internal Medicine Gunma University School Of Medicine
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TAKAHASHI Naoyuki
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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