ENHANCED RESPONSES TO PRESSOR STIMULI BY INTRACEREBROVENTRICULAR INFUSIONS OF ANGIOTENSIN II IN CONSCIOUS RATS
スポンサーリンク
概要
- 論文の詳細を見る
Effects of the intracerebroventricular (IVT) infusion of a subpressor dose (3 ng/kg/min) of angiotensin II (ang II) on the pressor responses to intravenous (IV) infusions of ang II and to IV bolus injections of norepinephrine (NE) were studied in conscious rats. This study was undertaken to determine whether activations of the brain renin-angiotensin system alter pressor responsiveness to IV infusions of ang II and IV injections of NE in the conscious state. Pressor responses to IV infusions of ang II and IV injections of NE were potentiated by the concurrent IVT infusion of the subpressor dose of ang II. Plasma renin activity (PRA), plasma corticosterone (B), and plasma prolactin concentration (PRL) were also measured before and during the IVT infusion of the subpressor (3 ng/kg/min) or the pressor (50 ng/kg/min) dose of ang II in order to determine the mechanisms for this pressor hyperresponsiveness to vasoconstrictor substances. The IVT subpressor dose of ang II increased PRA, but did not significantly change B and PRL. The IVT pressor dose of ang II decreased PRA and increased B, but did not significantly change PRL. These results suggest that the brain renin-angiotensin system plays an important role in pressor responsiveness to IV ang II and NE. Although the mechanisms are not fully understood, pressor hyperresponsiveness to IV ang II and NE by an intracerebroventricularly administered subpressor dose of ang II may be related to increased sympathetic outflow, because of the increment in PRA.
- 社団法人日本循環器学会の論文
- 1986-03-20
著者
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MURATA Kazuhiko
The Second Department of Internal Medicine,Gunma University School of MedicineThe Second Department
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Nakamura Tetsuya
Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine
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Masuda H
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Ichikawa Shuichi
Department Of Vascular Medicine Cardiovascular Hospital Of Central Japan (kitakanto Cardiovascular H
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NAKAMURA Tetsuya
The Second Department of Internal Medicine, Gunma University School of Medicine
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ONO Zenpei
Second Department of Internal Medicine, Gunma University School of Medicine
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SAKAMAKI Tetsuo
the Second Department of Internal Medicine, Gunma University School of Medicine
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ONO Zenpei
the Second Department of Internal Medicine, Gunma University School of Medicine
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Mizuno Haruyoshi
Valsartan and PWV Research Group
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Kumakura Hisao
Second Department Of Internal Medicine Gunma University School Of Medicine
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Sakamaki Tetsuo
Department Of Medical Informatics And Decision Sciences School Of Medicine Gunma University
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Ono Zenpei
Second Department Of Internal Medicine Gunma University School Of Medicine
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Ono Zenpei
2nd Department Of Internal Medicine Gunma University School Of Medicine
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Ono Zenpei
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Murata Kazuhiko
Departments Of Diagnostic Radiology Gunma University School Of Medicine
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Ichikawa Shuichi
The Second Department Of Internal Medicine Gunma University School Of Medicine
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MATSUO HIDEYO
The Second Department of Internal Medicine, School of Medicine. Gunma University
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HISAO KUMAKURA
The Second Department of Internal Medicine, School of Medicine. Gunma University
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Mizunuma Hideki
The Department Of Obstetrics And Gynecology Hirosaki University School Of Medicine
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Matsuo Hideyo
The Second Department Of Internal Medicine School Of Medicine. Gunma University
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Matsuo H
Second Department Of Internal Medicine University Of Tokyo
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Murata Kazuhiko
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Matsuo Hideyo
The Second Department Of Internal Medicine School Of Medicine Gunma University
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Sakamaki Tetsuo
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Murata Kazuhiko
The Second Department Of Internal Medicine Gunma University School Of Medicine Maebashi
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Nakajima Tadashi
Department Of Biochemistry And Molecular Dentistry Okayama University Graduate School Of Medicine An
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Murata Kazuhiko
The Second Department Of Internal Medicine And The Department Of Hygiene Gunma University School Of
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Murata Kazuhiko
The Second Department Of Internal Medicine Gunma University School Of Medicine Maebashi Japan
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Murata Kazuhiko
The Second Department Of Internal Medicine School Of Medicine Kanazawa University
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Murata K
The Second Department Of Internal Medicine Gunma University School Of Medicine
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