Effect of Ketanserin on Pressor Response to Vasoactive Substances in Early Phase of One-Kidney, One Clip Renal Artery Stenosis in Rats and Rabbits : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION

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The effect of ketanserin (KET), a specific 5-hydroxytryptamine_2 (5-HT_2) receptor blockade, on pressor response to vasoactive substances was examined in rats with one-kidney, one clip renal artery stenosis of 2 days' duration (2-day clipped rat) and in rabbits with renal artery stenosis of 3 days' duration (3-day clipped rabbits). The 2-day clipped rats showed hyperresponsiveness to norepinephrine (NE), arginine vasopressin (AVP) and 5-HT. All hyperresponsiveness were attenuated by a subdepressor dose of KET. The infusion of KET, 10 μg/kg/min for 30 minutes, decreased mean arterial pressure of the 3-day clipped rabbits ; the dose did not alter blood pressure of the normal controls. Exaggerated pressor response to NE was observed in the 3-day clipped rabbits and was abolished by a subdepressor dose of KET, 2.5 μg/kg/min. These results suggest that 5-HT may be involved in the enhanced pressor response to vasoconstrictor substances in the 2-day clipped rats and 3-day clipped rabbits, and that it may also play an important role in maintaining blood pressure in the 3-day clipped rabbits.
社団法人日本循環器学会の論文
1986-11-20