EFFECT OF DEXAMETHASONE OF THE DIURNAL RHYTHM OF PLASMA ALDOSTERONE IN PATIENTS WITH CONGESTIVE HEART FAILURE
スポンサーリンク
概要
- 論文の詳細を見る
Diurnal rhythm studies were performed on 11 patients with congestive heart failure. Blood samples were taken for the determination of aldosterone, cortisol and plasma renin activity every 4 hours from 12:00 a.m. to 12:00 a.m. the following day. Following this control study, a second diurnal rhythm study was conducted under dexamethasone treatment (0.5 mg of dexamethasone every 4 hours for 48 hours). In the control study, aldosterone and cortisol fluctuated showing a diurnal rhythm with the lowest value in the evening and the highest value in the morning. Plasma renin activity rhythm was indistinct. Fluctuations in plasma renin activity were not parallel with aldosterone. Dexamethasone treatment suppressed cortisol to less than 1 μg/100 ml. Aldosterone values decreased significantly in the morning (p<0.01); this was accompanied by the abolishment of aldosterone rhythm. Plasma renin activity rhythm remained indistinct following administration of dexamethasone. These results suggest that adrenocorticotrophic hormone plays an important role in the control of aldosterone diurnal rhythm in patients with congestive heart failure.
- 社団法人日本循環器学会の論文
- 1981-07-20
著者
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Masuda H
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Ichikawa Shuichi
Department Of Vascular Medicine Cardiovascular Hospital Of Central Japan (kitakanto Cardiovascular H
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SAKAMAKI Tetsuo
the Second Department of Internal Medicine, Gunma University School of Medicine
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Sakamaki Tetsuo
Department Of Medical Informatics And Decision Sciences School Of Medicine Gunma University
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Ichikawa Shuichi
The Second Department Of Internal Medicine Gunma University School Of Medicine
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MATSUO HIDEYO
The Second Department of Internal Medicine, School of Medicine. Gunma University
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Mizunuma Hideki
The Department Of Obstetrics And Gynecology Hirosaki University School Of Medicine
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Matsuo Hideyo
The Second Department Of Internal Medicine School Of Medicine. Gunma University
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Matsuo H
Second Department Of Internal Medicine University Of Tokyo
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Matsuo Hideyo
The Second Department Of Internal Medicine School Of Medicine Gunma University
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Sakamaki Tetsuo
The Second Department Of Internal Medicine Gunma University School Of Medicine
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