Estimation of Chemical Structure of Notopterol Metabolites
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概要
- 論文の詳細を見る
Notopterol, 5[(2E)-5-hydroxy-3,7-dimethyl-2,6-octadienyloxy]psoralen showed an inhibitory effect on aminopyrine N-demetylase activity in liver microsomes. In addition, notopterol has been found to be metabolized by cytochrome P450,and two kinds of metabolites were formed from notopterol. Furthermore, specific cytochrome P450 3A4 inhibitors which were isolated from grapefruit juice had the same furocoumarin structure as notopterol. Two metabolites of notopterol were separated by HPLC, and the chemical structures of the hydroxylated metabolites were estimated by ^1H-NMR spectra and liquid chromatography-mass spectrometry.
- 公益社団法人日本薬学会の論文
- 1999-07-15
著者
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Ishikawa Tsutomu
Faculty of Pharmaceutical Sciences, Chiba University
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Hasegawa A
Department Of Earth And Ocean Sciences National Defense Academy
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KITADA Mitsukazu
Division of Pharmacy, Chiba University Hospital
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OHMORI Shigeru
Division of Pharmacy, Shinshu University Hospital
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OKUYAMA Emi
Faculty of Pharmaceutical Sciences, Chiba University
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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WATANABE Toshiko
Faculty of Pharmaceutical Sciences, Josai University
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Ishikawa Tsutomu
Dep. Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Ishikawa Tsutomu
Faculty Of Pharmaceutical Sciences Chiba University
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Nakamura Hiroyoshi
Division Of Pharmacy University Hospital Chiba University School Of Medicine
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Watanabe Toshiko
Faculty Of Pharmaceutical Sciences Chiba University
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Kitada Mitsukazu
Division Of Pharmacy University Hospital Chiba University School Of Medicine
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Kitada Mitsukazu
Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Ishikawa T
Graduate School Of Pharmaceutical Sciences Chiba University
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HASEGAWA Atsushi
Division of Pharmacy, Chiba University Hospital, Faculty of Medicine, Chiba University
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Nakamura Hironori
Division Of Pharmacy University Hospital Chiba University School Of Medicine
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Okuyama Emi
Faculty Of Pharmaceutical Science Chiba University
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Ohmori S
Division Of Pharmacy Shinshu University Hospital
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Ohmori Shigeru
Division Of Pharmacy Shinshu University Hospital
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Watanabe T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Ishikawa Tsutomu
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Kimura Maharu
Division Of Pharmacy Chiba University Hospital
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Hasegawa Atsushi
Division Of Pharmacy Chiba University Hospital
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Ishikawa Toshihisa
Graduate School of Pharmaceutical Sciences, Chiba University
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