Stereoselectivity in Bunitrolol 4-Hydroxylation in Liver Microsomes from Marmosets and Japanese Monkeys
スポンサーリンク
概要
- 論文の詳細を見る
The stereoselectivity in 4-hydroxylation of bunitrolol (BTL), a β-adrenoreceptor blocking agent, was examined in liver microsomes from monkeys (marmosets and Japanese monkeys) and compared with the results of human liver microsomes. The formation of (+)-4-OH-BTL from (+)-BTL was significantly higher than that of (-)-4-OH-BTL from (-)-BTL in the liver microsomal fractions from the two kinds of monkeys. The 4-OH-BTL-forming activity from recemic BTL was significantly lower than that from enantiomeric BTL, indicating a possible metabolic interaction between BTL enantiomers. The in vitro profiles observed in the monkeys were very similar to those in humans, but the stereoselectivity in BTL metabolism [(+)-BTL>(-)-BTL] in the primates was found to be reverse to that in rats [S. Narimatus et al., Anal. Biochem., 222,256-261 (1994)]. The 4-OH-BTL-forming activity from BTL enantiomers was significantly suppressed by quinidine and quinine, while the former was more potent than the latter, and also by α-naphthoflavone. Furthermore, the activity was also suppressed by antisera against rat cytochromes P450-2D2 and -1A2 in concentration-dependent manners. However, kinetics showed that enantiomeric BTL 4-hydroxylation was monophasic in liver microsomes from marmosets of both genders and from male Japanese monkeys. These results suggest that cytochrome P450-2D and -1A enzymes with similar K_m values are involved in BTL 4-hydroxylation in monkey liver microsomes.
- 社団法人日本薬学会の論文
- 1996-11-15
著者
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澤山 茂
東京農大・栄養
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NARIMATSU Shizuo
Laboratories of Health Chemistry,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
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YAMAMOTO IKUO
Department of Laboratory Medicine, Miyazaki Medical College
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桝渕 泰宏
千葉大・院・薬
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景山 節
京大・霊長類研・生化学
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堀江 利治
千葉大 大学院薬学研究院
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Yamamoto Ikuo
Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W
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KITADA Mitsukazu
Division of Pharmacy, Chiba University Hospital
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KAGEYAMA Takashi
Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University
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Suzuki T
Departments Of Biopharmaceutice Graduate School Of Pharmaceutical Sciences Chiba University
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Suzuki Tokuji
Laboratory Of Biophermaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Yamamoto Ikuo
北陸大学 薬 衛化
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Yamamoto Ikuo
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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OHMORI Shigeru
Division of Pharmacy, Shinshu University Hospital
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GOTOH Masumi
Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University
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MASUBUCHI Yasuhiro
Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University
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HORIE Toshiharu
Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University
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ASAOKA Kazuo
Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University
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YAMAMOTO IKUO
Hygienic Chemistry
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Kimura T
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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景山 節
京都大学霊長類研究所人類進化モデル研究センター
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景山 節
京大・霊長研
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Suzuki Tokuji
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Narimatsu Shizuo
Laboratories Of Health Chemistry Okayama University
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Narimatsu Shizuo
Laboratories Health Chemistry Faculty Of Pharmaceutical Sciences Okayama University
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Kitada Mitsukazu
Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Kitada Mitsukazu
Division Of Pharmacy School Of Medicine Chiba University Hospital
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Masubuchi Y
Laboratory Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Chiba Institute Of Scienqes
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Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
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Gotoh M
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Asaoka Kazuo
Department Of Cellular And Molecular Biology Primate Research Institute Kyoto University
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Ohmori Shigeru
Division Of Pharmacy Shinshu University Hospital
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Suzuki Tsuguyoshi
Departments Of Biopharmaceutice Graduate School Of Pharmaceutical Sciences Chiba University
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Yamamoto I
Hygienic Chemistry
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澤山 茂
東京農大 栄養
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Yamamoto Ikuo
Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University
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Kimura T
Peptide Inst. Inc. Minoh Jpn
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Ohmori Shigeru
Dep. Of Pharmacy Shinshu Univ. Hospital
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