Anandamide, an Endogenous Cannabinoid Receptor Ligand, Also Interacts with 5-Hydroxytryptamine (5-HT) Receptor

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概要

• 論文の詳細を見る

• Interactions of anandamide (N-arachidonylethanolamide), an endogenous compound for cannabinoid receptors, with the receptors for 5-hydroxytryptamine (5-HT), benzodiazepine, and γ-aminobutyric acid_A (GABA_A) receptors in bovine synaptic membrane were examined. Anandamide decreased the 5-HT receptor bindings at concentrations of 1-100 μM, although it did not cause any change in benzodiazepine or GABA_A receptor bindings. A high concentration of anandamide, 100μM, significantly decrease both [^3H]5-HT and [^3H]ketanserin bindings. The present study revealed that the pharmacological activity of anandamide might be partially mediated through the 5-HT receptor.

• 公益社団法人日本薬学会の論文
• 1998-03-15

著者

• YAMAMOTO IKUO

  Department of Laboratory Medicine, Miyazaki Medical College

• 景山 節

  京大・霊長類研・生化学

• Yamamoto Ikuo

  Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W

• Kimura Toshiyuki

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• Watanabe Kazuhito

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• Ohta T

  Hayashibara Biochemical Lab. Inc. Okayama Jpn

• Ohta Tomoko

  Department Of Bioresources Chemistry Faculty Of Horticulture Chiba University

• YOSHIMURA Hidetoshi

  Department of Food and Nutrition, Nakamura Gakuen University

• Yamamoto Ikuo

  北陸大学 薬 衛化

• Yamamoto Ikuo

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• YAMAMOTO IKUO

  Hygienic Chemistry

• Kimura T

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• 景山 節

  京都大学霊長類研究所人類進化モデル研究センター

• 景山 節

  京大・霊長研

• Kimura Toshiyuki

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Watanabe Kazuhito

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Watanabe Kazuhito

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University

• Yoshimura Hidetoshi

  Department Of Food And Nutrition Nakamura Gakuen University

• Yoshimura Hidetoshi

  Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam

• Kimura T

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Yoshida H

  Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.

• Yamamoto I

  Hygienic Chemistry

• Yoshida Hiromi

  Department Of Nutritional Science Kobe Gakuin University

• Watanabe Kazuhito

  Faculty Of Pharmaceutical Sciences Kyushu University

• Yoshimura Hidetoshi

  Department Of Food And Nutrition Nakamura Gakuen

• Yamamoto Ikuo

  Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University

• Kimura T

  Peptide Inst. Inc. Minoh Jpn

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