Hypnotic Action of N^3-Substituted Arabinofuranosyluracils on Mice
スポンサーリンク
概要
- 論文の詳細を見る
Methyl(2), ethyl(3), propyl(4), butyl(5), allyl(6), benzyl(7), o-, m-, p-xylyl(8-10), and α-phenylethyl(11)derivatives of arabinofuranosyluracil(1)were synthesized and their pharmacological effects in mice were examined by using hypnotic activity and synergism with pentobarbital as indices for the CNS depressant effects. At a dose of 2.0 μmol/mouse by intracerebroventricular injection, the values of mean sleeping time induced by 7-11 were 144, 154, 117, 33, and 34min, respectively, whereas the alkyl(2-6)derivatives did not cause any hypnotic activity. N^3-o-Xylylarabinofuranosyluracil(8)displayed the most potent hypnotic activity among the derivatives tested. Certain derivatives(6-11)significantly prolonged the pentobarbital-induced sleeping time compared to control. The present study indicated that substitution with benzyl and/or related groups on the N^3-position of arabinofuranosyluracil produced CNS depressant effects.
- 社団法人日本薬学会の論文
- 2001-01-01
著者
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景山 節
京大・霊長類研・生化学
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Yamamoto Ikuo
Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W
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Watanabe Kazuhito
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Yamamoto Ikuo
Faculty of Education, Yokohama National University
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Kondo Shigemi
Nissui Pharmaceutical Co. Ltd.
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WATANABE Kazuhito
Faculty of Pharmaceutical Sciences, Hokuriku University
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KIMURA Toshiyuki
Faculty of Pharmaceutical Sciences, Hokuriku University
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YAMAMOTO Ikuo
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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HO Ing
University of Mississippi Medical Center
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HO Ing
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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YAO Shechun
Faculty of Pharmaceutical Sciences, Hokuriku University
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Yamamoto Ikuo
北陸大学 薬 衛化
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YAMAMOTO IKUO
Hygienic Chemistry
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Kimura T
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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景山 節
京都大学霊長類研究所人類進化モデル研究センター
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景山 節
京大・霊長研
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Ho Ing
ミシシッピ大学医学部薬毒理学教室
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Watanabe Kazuhito
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
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Kimura Toshiyuki
Faculty Of Engineering Yokohama National University
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Ho Ing
Department Of Pharmacology & Toxicology University Of Mississippi Medical Center
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Yao Shechun
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kondo S
Kyoritsu Coll. Pharmacy Tokyo Jpn
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Yamamoto I
Hokuriku Univ. Kanazawa Jpn
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Kondo Shin-ichi
Dep. Of Pharmaceutical Physical Chemistry Gifu Pharmaceutical Univ.
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto I
Hygienic Chemistry
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto Ikuo
Hygienic Chemistry School Of Pharmacy Hokuriku University
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Yamamoto Ikuo
Faculty Of Education Yokohama National University
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Kimura T
Peptide Inst. Inc. Minoh Jpn
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