INHIBITION OF ANANDAMIDE AMIDASE ACTIVITY IN MOUSE BRAIN MICROSOMES BY CANNABINOIDS

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概要

• 論文の詳細を見る

• Mouse brain microsomes contain an amidase that catalyzes the hydrolysis of N-arachidonylethanolamide to arachidonic acid and ethanolamine. The enzymatic activity is dependent on the protein concentration of the microsomes and observed over a wide range of pH, 7.4 to 9.5. Kinetic analysis indicated that Km (μM) and Vmax (nmol/min/mg protein) were 17.7 ± 4.1 and 1.81 ± 0.32,respectively. Cannabidiol (CBD), cannabinol (CBN) and Δ^9-tetrahydrocannabinol (Δ^9-THC) significantly inhibited the hydrolysis of the amide by mouse brain microsomes. At a concentration of 160 μM, the inhibitory potency decreased in the following order, CBD(66%)>CBN(46%)>Δ^9-THC(31%).

• 公益社団法人日本薬学会の論文
• 1996-08-15

著者

• Yamamoto Ikuo

  Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And W

• Yamamoto Ikuo

  北陸大学 薬 衛化

• Yamamoto Ikuo

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Kayano Yuichiro

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• YAMAMOTO IKUO

  Hygienic Chemistry

• Kayano Y

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Kayano Yuichiro

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Watanabe Kazuhito

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Watanabe Kazuhito

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University

• Yoshimura Hidetoshi

  Department Of Food And Nutrition Nakamura Gakuen University

• Yoshimura Hidetoshi

  Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam

• Yoshida H

  Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.

• Yamamoto I

  Hygienic Chemistry

• Yoshida Hiromi

  Department Of Nutritional Science Kobe Gakuin University

• Matsunaga Tamihide

  Department Of Pharmacy Shinshu University Hospital

• Watanabe Kazuhito

  Faculty Of Pharmaceutical Sciences Kyushu University

• Yoshimura Hidetoshi

  Department Of Food And Nutrition Nakamura Gakuen

• Yamamoto Ikuo

  Department Of Bioapplied Chemistry Faculty Of Engineering Osaka City University

• Matsunaga Tamihide

  Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University

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