IDENTIFICATION AND DETERMINATION OF 11-OXO-Δ^8-TETRAHYDROCANNABINOL AS AN INTERMEDIATE METABOLITE OF Δ^8-TETRAHYDROCANNABINOL IN THE MOUSE BRAIN AND LIVER
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概要
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11-Oxo-Δ^8-tetrahydrocannabinol (11-oxo-Δ^8-THC) was found in the mouse brain and liver extracts as a new in vivo metabolite of Δ^8-THC. The metabolite was detected by thin-layer chromatography using two aldehyde reagents together with a phenol reagent and identified as a heptafluorobutyrate by ECD-gas chromatography. This identification was further supported by gas chromatography-mass spectrometry. Content of the metabolite in the mouse liver was 0.09 or 0.19 μg/g at 15 min after the i. v. injection of Δ^8-THC or 11-hydroxy-Δ^8-THC (11-OH-Δ^8-THC) at a dose of 10 mg/kg. On the contrary, 11-oxo-Δ^8-THC was not precisely quantified (<0.01 μg/g) in the brain after the injection of Δ^8-THC, although its content after the injection of 11-OH-Δ^8-THC was 0.03 μg/g.
- 社団法人日本薬学会の論文
著者
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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YAMAMOTO Ikuo
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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OGURI Kazuta
Faculty of Pharmaceutical Sciences, Kyushu University
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Yamamoto Ikuo
北陸大学 薬 衛化
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Yamamoto Ikuo
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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WATANABE KAZUHITO
School of Pharmacy, Hokuriku University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri Kazuta
School Of Pharmacy Hokuriku University
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto Ikuo
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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