Species Difference of Site-Selective Glucuronidation of Morphine
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概要
- 論文の詳細を見る
Species difference in glucuronidation of morphine was studied using mice, rats, guinea pigs and rabbits in vivo and in vitro. Morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G) were determined by high-performance liquid chromatography. M-3-G was the major urinary metabolite of morphine in all these animal species. However, a remarkable species difference was observed in the urinary excretion of the M-6-G. Excretion ratios of the M-3-G to M-6-G were approximately 4 : 1 and 50 : 1 in guinea pigs and rabbits, respectively. The urinary excretion of M-6-G in mice and rats was too small to be determined. On the other hand, the ratios of uridine diphosphateglucuronyltransferase (UDPGT) activities toward 3-and 6-hydroxyl groups of morphine in liver microsomes of mice, rats, guinea pigs and rabbits were approximately 300 : 1,90 : 1,4 : 1 and 40 : 1,respectively. Ratios of two morphine UDPGT activities in the liver microsomes of guinea pigs and rabbits, thus, reflected those of urinary excretion of morphine glucuronides.
- 公益社団法人日本薬学会の論文
著者
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Nokihara Hiroshi
Thoracic Oncology Division National Cancer Center Hospital National Cancer Center
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Nokihara Hiroshi
国立がんセンター中央病院 呼吸器グループ
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Niki Hisae
国立がんセンター中央病院 消化器内科
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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OGURI Kazuta
Faculty of Pharmaceutical Sciences, Kyushu University
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Kuo Ching
Faculty Of Pharmaceutical Sciences Kyushu University
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HANIOKA NOBUMITSU
Faculty of Pharmaceutical Sciences, Kyushu University(Present)
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Hanioka Nobumitsu
Faculty Of Pharmaceutical Sciences Kyushu University
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Hanioka Nobumitsu
Faculty Of Pharmaceutical Sciences Kyushu University(present):national Institute Of Hygienic Science
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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HOSHIKAWA Youichi
Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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