SUPPRESSIVE EFFECT OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID ON INDUCTION OF URIDINE DIPHOSPHATE-GLUCURONYLTRANSFERASES AND MONOOXYGENASES IN LIVER MICROSOMES OF RATS

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概要

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• The effect of polyriboinosinic acid-polyribocytidylic acid [poly (I)・poly (C)] on glucuronyltransferase activities toward 4-nitrophenol and 4-hydroxybiphenyl in liver microsomes of Wistar rats was examined by its single or co-administration with 3-methylcholanthrene and phenobarbital. The increased 4-nitrophenol glucuronyltransferase activity by treatment with 3-methylcholanthrene was significantly suppressed following the coadministration with poly (I)・poly (C), although the activity was not affected by the treatment with poly (I)・poly (C) alone. In addition, 4-hydroxybiphenyl glucuronyltransferase activity decreased or tended to decrease by the treatment with poly (I)・poly (C) alone, and the activity induced by phenobarbital was strikingly decreased following the co-administration with poly (I)・poly (C). This result suggested that poly (I)・poly (C) comprehensively decrease the induction of glucuronyltransferases regardless of their multiple forms. Furthermore, contents of cyto chromes P-450 and b_5 were also decreased by the treatment with poly (I)・poly (C) alone or the co-administration with the inducers. Concomitantly, arylhydrocarbon hydroxylase and benzphetamine N-demethylase activities were significantly decreased by the treatment alone or the co-administration with the inducers. These findings supported a view that the suppressive effect of poly (I)・poly (C) may be derived from the prevention of de novo synthesis of the apoprotein of the enzymes and/or the increased degradation.

• 公益社団法人日本薬学会の論文

著者

• Nagata Kiyoshi

  九州大学 薬

• Nagata Kiyoshi

  Faculty Of Pharmaceutical Sciences Kyushu University

• Nokihara Hiroshi

  Thoracic Oncology Division National Cancer Center Hospital National Cancer Center

• Nokihara Hiroshi

  国立がんセンター中央病院 呼吸器グループ

• Niki Hisae

  国立がんセンター中央病院 消化器内科

• YOSHIMURA HIDETOSHI

  Faculty of Pharmaceutical Sciences, Kyushu University

• MATSUNAGA Tamihide

  Faculty of Pharmaceutical Sciences, Hokuriku University

• OGURI Kazuta

  Faculty of Pharmaceutical Sciences, Kyushu University

• Tanaka Eiji

  Faculty Of Pharmaceutical Sciences Kyushu University

• HANIOKA NOBUMITSU

  Faculty of Pharmaceutical Sciences, Kyushu University(Present)

• Hanioka Nobumitsu

  Faculty Of Pharmaceutical Sciences Kyushu University

• Hanioka Nobumitsu

  Faculty Of Pharmaceutical Sciences Kyushu University(present):national Institute Of Hygienic Science

• Yoshimura Hidetoshi

  Faculty Of Pharmaceutical Sciences Kyushu University

• Yoshimura Hidetoshi

  Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam

• BUPPODOM PORNTIP

  Faculty of Pharmaceutical Sciences, Kyushu University

• Oguri Kazuta

  Faculty Of Pharmaceutical Sciences Kyushu University

• Oguri K

  Faculty Of Pharmaceutical Sciences Kyushu University

• Oguri K

  Kyushu Univ. Fukuoka Jpn

• Tanaka E

  Univ. Tsukuba Ibaraki Jpn

• Mitsui Tetsuya

  Faculty Of Pharmaceutical Sciences Kyushu University

• Yoshimura H

  Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam

• Matsunaga Tamihide

  Faculty Of Pharmaceutical Sciences Kyushu University

• Buppodom Porntip

  Faculty Of Pharmaceutical Sciences Kyushu University

• Yoshimura Hidetoshi

  Department Of Food And Nutrition Nakamura Gakuen

• Nagata K

  Faculty Of Pharmaceutical Sciences Kyushu University

• Tanaka Eiji

  Faculty Of Marine Science Tokyo University Of Marine Science And Technology

• MATSUNAGA TAMIHIDE

  Faculty of Pharmaceutical Sciences, Kyushu University

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