HIGH ACCUMULATION OF 2,3,4,7,8-PENTACHLORODIBENZOFURAN TO HEPATIC MICROSOMES OF RATS
スポンサーリンク
概要
- 論文の詳細を見る
The tissue and subcellular distribution of ^<14>C-2,3,4,7,8-pentachlorodibenzofuran (PenCDF), one of the most important causal agents of Yusho, were studied using rats. More than 60% of the radioactivity given orally was accumulated in the liver after 5d and this high percentage persisted over a period of 3 weeks. Subcellular fractionation of the liver homogenate showed unusual separation by PenCDF-pretreatment, but the distribution of radioactivity was just parallel to those of cytochrome P-450 content and glucose-6-phosphatase (EC3.1.3.9) activity. Gas chromatographic analysis provided evidence that the extracts from the liver and its subcellular fractionations contained only unchanged PenCDF. Those results strongly suggest that PenCDF has some affinity to endoplasmic reticulum of rat liver.
- 公益社団法人日本薬学会の論文
著者
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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Koga N
Department Of Food And Nutrition Nakamura Gakuen University
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Koga Nobuyuki
Faculty Of Pharmaceutical Sciences Kyushu University
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Koga Nobuyuki
九州大学 薬研究院
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Koga Nobuyuki
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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MASUDA YOSHITO
Daiichi College of Pharmaceutical Sciences
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KUROKI HIROAKI
Daiichi College of Pharmaceutical Sciences
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KUROKI JUN
Faculty of Pharmaceutical Sciences, Kyushu University
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FUKASAKU NOBORU
Daiichi Pure Chemical Co., Ltd.
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HASEGAWA MASARU
Daiichi Pure Chemical Co., Ltd.
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Fukasaku Noboru
Daiichi Pure Chemical Co. Ltd.
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Kuroki Jun
Faculty Of Pharmaceutical Sciences Kyushu University
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Masuda Yoshito
Daiichi Coll. Of Pharm. Sci.
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Hasegawa Masaru
Daiichi Pure Chemical Co. Ltd.
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Koga Nobuyuki
Faculty of Nutritional Sciences, Nakamura Gakuen University
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