STUDIES ON CIS-TRANS ISOMERIZATION OF NITROFURAN DERIVATIVES BY BACTERIAL NITROREDUCTASES
スポンサーリンク
概要
- 論文の詳細を見る
cis-trans Isomerization of 3-(5-nitro-2-furyl)-2-(2-furyl)-acrylamide(AF-2) using Escherichia coli B/r and its two 5-nitro-2-furaldehyde semicarbazone(nitrofurazone)-resistant mutants was investigated. The isomerizing activity was detected in all three strains and markedly increased with acquiring resistance to nitro-furazone in intact cells and cell free extracts. Two distinct isomerases, nicotinamide adenine dinucleotide phosphate(NADPH)-dependent one with high activity and NAD(P)H-dependent with low activity were separate by sephadex G-100 and Sepharose 4B columns. Both enzyme activities agreed with the nitrofurazone-reducing activity due to O_2-sensitive nitroreductase as reported previously. Another nitroreductase, 0_2-insensitive one, was unable to isomerize cis AF-2 to trans form. These results suggest that bacterial cis-trans isomerases are not O_2-insensitive nitroreductase, but O_2-sensitive ones.
- 公益社団法人日本薬学会の論文
著者
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TATSUMI Kiyoshi
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Tatsumi Kiyoshi
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Tatsumi Kiyoshi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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KOGA HIDEO
Faculty of Pharmaceutical Sciences, Kyushu University
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HORIUCHI TADAO
Faculty of Pharmaceutical Sciences, Kyushu University
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Koga Nobuyuki
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Koga Hideo
Faculty Of Pharmaceutical Sciences Kyushu University
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Horiuchi Tadao
Faculty Of Pharmaceutical Sciences Kyushu University
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KOGA NOBUYUKI
Faculty of Pharmaceutical Sciences, Kyushu University
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Koga Nobuyuki
Faculty of Nutritional Sciences, Nakamura Gakuen University
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