Reductive Metabolism of Stilbene Oxide and Styrene Oxide to the Olefins in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The present study provides the first evidence that stilbene oxide and styrene oxide are reductively metabolized to the corresponding olefins in rats. When cis- or trans-stilbene oxide was given orally to rats, both cis- and trans-stilbene were isolated from the urine and feces. Styrene was also isolated from the urine and feces of rats given styrene oxide. These metabolites were identified unequivocally by UV and mass spectral comparison with authentic samples, and on the basis of their TLC and HPLC behavior. However, these olefins were not detected in the urine or faces of antibiotics-treated rats dosed with cis- or trans-stilbene oxide. Cecal contents of the untreated rats exhibited olefin oxide reductase activities toward cis- and trans-stilbene oxides under anaerobic conditions. The results suggest that intestinal bacteria play an important role in the reduction of olefin oxides to the corresponding olefins in the animal body.
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
-
KITAMURA Shigeyuki
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
-
TATSUMI Kiyoshi
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
-
Tatsumi Kiyoshi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
-
Shigeyuki Kitamura
Nihon Pharmaceutical University
-
Kitamura Shigeyuki
広島大学 総合薬
-
Mita Masashi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
-
Tatsumi K
Hiroshima Univ. School Of Medicine Hiroshima Jpn
-
Kitamura Shigeyuki
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
-
Kitamura Shigeyuki
Institute Of Pharmaceutical Science. Hiroshima University School Of Medicine
-
Tatsumi K
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
-
SHIRAISHI Yoshiki
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
-
SUEKI Hiromi
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
-
MAEDA Chiharu
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
-
Sueki Hiromi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
-
Maeda Chiharu
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
-
Shiraishi Yoshiki
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
関連論文
- Further Metabolism of 2-Formylaminofluorene, a Metabolite of 2-Aminofluorene, in Rats
- EFFECT OF A HIGH MAGNETIC FIELD ON AMPHIBIANS(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- ROLE OF MAMMALIAN TISSUES AND INTESTINAL BACTERIA IN N-ACYLATION
- N-ACYLATION OF ARYLAMINES IN DOGS
- Metabolism of Nitropolycyclic Aromatic Hydrocarbons and Related Compounds
- Disruption of Thyroid Hormone Function by Environmental Pollutants
- The effect of hypergravity on bipolar spindle formation of meiosis II in Xenopus oocytes
- Effects of Stilbene and Related Compounds on Reproductive Organs in B6C3F1/Crj Mouse
- Interconversion between Fenthion and Fenthion Sulfoxide in Goldfish, Carassius auratus
- Effect of Fenthion on the Level of Vitellogenin in Goldfish, Carassius auratus
- Reductive Dechlorination of p, p'-DDT Mediated by Hemoproteins in the Hepatopancreas and Blood of Goldfish, Carassius auratus
- STUDIES ON CIS-TRANS ISOMERIZATION OF NITROFURAN DERIVATIVES BY BACTERIAL NITROREDUCTASES
- Metabolism of Nitropolycyclic Aromatic Hydrocarbons in Animals, Fish and Intestinal Bacteria (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Role of Mammalian Enzymes and Intestinal Bacteria in the Metabolism of Nitropolycyclic Aromatic Hydrocarbons (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Metabolism of Carcinogenic Arylamines : N-Acylation (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Metabolism of Nicotine Related Compounds. Reduction of Nicotine-1'-N-oxide. (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- FUNCTION OF CATALASE AS A N-OXIDES REDUCTASE
- ROLE OF LIVER ALDEHYDE OXIDASE IN DRUG REDUCTION
- Studies on the Metabolism of Nitropolycyclic Aromatic Hydrocarbons (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- INVOLVEMENT OF LIVER ALDEHYDE OXIDASE IN CONVERSION OF N-HYDROXYURETHANE TO URETHANE
- Affinity for Thyroid Hormone and Estrogen Receptors of Hydroxylated Polybrominated Diphenyl Ethers
- Metabolic Activation of Proestrogens in the Environment by Cytochrome P450 System
- Effects of Environmental Antiandrogenic Chemicals on Expression of Androgen-Responsive Genes in Rat Prostate Lobes
- Quantitative Determination of Lobe Specificity of mRNA Expression of Androgen-dependent Genes in the Rat Prostate Gland
- Estrogen enhancement of androgen-responsive gene expression in hormone-induced hyperplasia in the ventral prostate of F344 rats
- Estrogenic Activity of Stilbene Derivatives
- Metabolic Activation of Proestrogenic Diphenyl and Related Compounds by Rat Liver Microsomes
- ヒト肝細胞を有するキメラマウスを用いた S-^3H-warfarin のヒト体内動態の予測
- Effects of Endocrine Disrupting Chemicals on Amphibian Metamorphosis and Mitochondrial Membrane Permeability Transition
- Novel Metabolic Pathways of p-n-Nonylphenol Catalyzed by Cytochrome P450 and Estrogen Receptor Binding Activity of New Metabolites
- 抗腫瘍剤の代謝酵素であるアルデヒドオキシダーゼは, 生まれたての小児には備わっていない
- In vivo-In vitro Relationship of Methotrexate 7-Hydroxylation by Aldehyde Oxidase in Four Different Strain Rats
- Effect of Green Tea Beverages on Efficacy of Povidone-lodine
- Drug-Metabolizing Ability of Molybdenum Hydroxylases
- Suppression of Amphibian Metamorphosis by Bisphenol A and Related Chemical Substances
- SUPPRESSION OF THYROID HORMONE-INDUCED TADPOLE TAIL APOPTOSIS BY BISPHENOL A AND RELATED CHEMICAL SUBSTANCES(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Deacylation of N-Formylanilines and N-Acetylanilines by Rat Liver Formamidase
- Cytochrome P450 1A1/2 Mediated Metabolism of trans-Stilbene in Rats and Humans
- Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver
- Nonenzymatic Reduction of N-Hydroxy-2-acetylaminofluorene to 2-Acetylaminofluorene by Heme in the presence of Hydroquinones
- Effects of High Gravity on Amphibian Development
- Conversion of Dieldrin to Aldrin by Intestinal Bacteria in Rats
- SUPPRESSION OF T_3-INDUCED TADPOLE TAIL ATROPHY BY PARA-NONYLPHENOL(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Reductive Metabolism of Stilbene Oxide and Styrene Oxide to the Olefins in Rats
- Quinone-Dependent Tertiary Amine N-Oxide Reduction in Rat Blood
- Studies on the Reductive Metabolism of Olefin Oxides (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- The Reductive Metabolism of trans-4-Phenyl-3-buten-2-one in Rats(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- HIGH GRAVITY INHIBITS EMBRYONIC DEVELOPMENT OF AMPHIBIANS(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- THE EFFECT OF HIGH GRAVITY ON AMPHIBIAN DEVELOPMENT(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Studies on Reductive Metabolism of Aromatic Nitro Compounds (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- Metabolism of Nitropolycyclic Aromatic Hydrocarbons in Fish (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- METABOLISM OF N-HYDROXYURETHANE BY GUINEA PIG LIVER PREPARATIONS
- Purification and Some Properties of Hamster Liver Aldehyde Oxidase
- ENZYMES INVOLVED IN DEHYDROXYLATION OF A CARCINOGEN N-HYDROXY-2-ACETYLAMINOFLUORENE
- A New Mechanism for Reduction of Carcinogenic Hydroxamic Acids
- A COMPARATIVE STUDY ON 1-NITROPYRENE AND NITROFURAZONE REDUCTASES IN ESCHERICHIA COLI
- Enzymes Responsible for Reduction of Nitropolycyclic Aromatic Hydrocarbons (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- STUDIES ON BACTERIAL NITROREDUCTASES. ENZYMES INVOLVED IN REDUCTION OF AROMATIC NITRO COMPOUNDS IN ESCHERICHIA COLI
- Stereoselective determination of R,S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and its taurine conjugates in dog urine by high-performance liquid chromatography
- SULFOXIDE REDUCTION CATALYZED BY GUINEA PIG LIVER ALDEHYDE OXIDASE IN COMBINATION WITH ONE-ELECTRON REDUCING FLAVOENZYMESS
- SULFOXIDE REDUCTASE ACTIVITY OF LIVER ALDEHYDE OXIDASE AND A NEW ELECTRON TRANSFER SYSTEM CONTAINING THE ENZYME AS A COMPONENT
- SOLUBLE FACTOR-INVOLVING REDUCTION IN DRUG METABOLISM
- Azoreductase Activity of Liver Aldehyde Oxidase (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- DT-Diaphorase-Like Quinone Reductase in Rat Plasma
- Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity : A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver
- IN VITRO METABOLISM OF SULINDAC AND SULINDAC SULFIDE: ENZYMATIC FORMATION OF SULFOXIDE AND SULFONE
- A New Mechanism for Biotransformation of Nitrofuran Derivatives : Metabolism of Nifurstyrenic Acid, a Veterinary Antimicrobial Agent, in Animals and Fishes (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicol
- A NEW MECHANISM OF N-OXIDE REDUCTION : QUINONE-DEPENDENT REACTION
- MECHANISM FOR BIOTRANSFORMATION OF AN ALIPHATIC AMINE VIA THE CORRESPONDING OXIME
- Metabolism in Vivo of 1-Nitropyrene, an Environmental Pollutant, in Fish
- STUDIES ON BIOACTIVATION OF NITROSAMINES. REDUCTIVE METABOLISM OF A NITROSAMINE TO THE CORRESPONDING HYDRAZINE
- Mechanism of Reduction of Epoxide Compounds in Animal Body (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- A NEW DRUG-METABOLIZING ENZYME WITH ABILITY TO REDUCE DOUBLE BOND
- Induction of Xanthine Dehydrogenase by TCDD(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)