Effect of Green Tea Beverages on Efficacy of Povidone-lodine
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概要
- 論文の詳細を見る
Povidone-iodine (PVP-I) gargling solution is used to prevent bacterial infection, but because of its unpleasant smell and metallic taste, people often drink a flavoring agent, such as green tea, immediately after gargling. Green tea beverages, however, have antioxidant activity and may decrease the antibacterial activity of PVP-I. In this study, we investigated the interaction between green tea beverages and PVP-I. Addition of O-i ocha^[○!R] or O-i ocha koiaji^[○!R] caused color changes of PVP-I from amber to yellow-brown or to orange-yellow, respectively. Ascorbic acid (0.03 mg/ml) caused no color change in PVP-I. The antioxidant activity was highest in O-i ocha koiaji^[○!R], followed by Hajime^[○!R], Nama cha^[○!R], O-i ocha^[○!R], and Flavancha^[○!R] in that order. Sou ken bi cha^[○!R] and ascorbic acid (0.03 mg/ml) showed poor antioxidant activity. All six green tea beverages that we examined inhibited the antibacterial activity of PVP-I towards Streptococcus salivarius, Streptococcus mutans (S. mutans) and Streptococcus sanguis (S. sanguis). O-i ocha koiaji^[○!R] showed the most potent inhibitory activity. The antioxidant activity was significantly correlated with the minimum inhibitory dilution ratio of green tea beverages for S. sanguis (r=0.763,p<0.05) and 5. mutans (r=0.854,p<0.01). These findings indicate that green tea beverages reduce the antibacterial activity of PVP-I in proportion to their antioxidant activity. In conclusion, beverages with antioxidant activity, such as green tea beverages, should not be consumed immediately after PVP-I gargling.
- 公益社団法人日本薬学会の論文
- 2006-06-01
著者
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OHTA Shigeru
Graduate School of Biomedical Sciences, Hiroshima University
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Shigeyuki Kitamura
Nihon Pharmaceutical University
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Kitamura Shigeyuki
広島大学 医学部総合薬学科生体機能分子動態学
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Kitamura Shigeyuki
広島大学 総合薬
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Kitamura Shigeyuki
広島大学原爆放射能医学研究所
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KITAMURA Shigeyuki
Graduate School of Biomedical Science, Hiroshima University
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MORITA SHUSHI
Faculty of Pharmaceutical Sciences, Kyoto University
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Sugihara Kazumi
Graduate School of Biomedical Sciences, Hiroshima University
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Sugihara K
Graduate School Of Biomedical Sciences Hiroshima University
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TAYAMA Yoshitaka
Division of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University
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Tayama Yoshitaka
Faculty of Pharmaceutical Science, Hiroshima International University
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Miyake Katsushi
Faculty of Pharmaceutical Science, Hiroshima International University
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Kobayashi Masao
Graduate School of Biomedical Sciences, Hiroshima University
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Kihira Kenji
Graduate School of Biomedical Sciences, Hiroshima University
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Kihira Kenji
Graduate School Of Biomedical Sciences Hiroshima University
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Miyake Katsushi
Faculty Of Pharmaceutical Science Hiroshima International University
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Ohta S
Graduate School Of Biomedical Sciences Hiroshima University
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Tayama Yoshitaka
Division Of Medicinal Chemistry Graduate School Of Biomedical Sciences Hiroshima University
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science. Hiroshima University School Of Medicine
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Morita Shushi
Faculty Of Pharmaceutical Science Hiroshima International University
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Ohta Shigeru
Graduate School Of Biomedical Sciences Hiroshima Univ.
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Kitamura Shigeyuki
Graduate School Of Bioagricultural Sciences Nagoya University
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Kobayashi Masao
Graduate School Of Biomedical Sciences Hiroshima University
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SUGIHARA Kazumi
Graduate School of Biomedical and Health Sciences, Hiroshima University
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