Spontaneous Tumors in Hypocatalasemic C3H/C^b_s/Gen and C3H Mice
スポンサーリンク
概要
- 論文の詳細を見る
Hypocatalasemic mice (Cbs) were examined for their life span and compared to C3H mice with reference to oxidase enzyme activity and spontaneous tumor development. N1-methylnicotinamice oxidase, xanthine oxidase (XO), xanthine dehydrogenase (XDH), and XO+XDH activities in 8 week-old male Cbs mice were decreased as compared to the C3H counterparts. On the other hand, benzaldehyde oxidase in both sexes and xanthine dehydrogenase activity in females were significantly elevated as compared to the C3H. The total tumor incidence, number of tumors per mouse, liver tumors, and other tumor induction were significantly greater in as compared with until 499 days group in both sexes (P<0.01). The total incidence of tumors and incidence of liver tumors were not significantly different between the two strains in both sexes. The number of tumors per animal in C3H females and incidence of sarcoma in both sexes were significantly decreased as compared with the Cbs case but the numbers of liver tumor per animal and ovarian tumors were significantly greater.
- 日本毒性病理学会の論文
- 2004-03-30
著者
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WATANABE Hiromitsu
Department of Cancer Research, Hiroshima University
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Katoh Osamu
Department of Cardiology, Toyohashi Heart Center
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Kashiwabara Shoji
Graduate School Of Biomedical Science Hiroshima University
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KASHIWABARA Shoji
Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Uni
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KIN Keishi
Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Uni
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SUGIURA Kazumi
Graduate School of Biomedical Science, Hiroshima University
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KITAMURA Shigeyuki
Graduate School of Biomedical Science, Hiroshima University
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KASHIMOTO Naoki
Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Uni
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UESAKA Toshihiro
Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima Uni
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Kashimoto Naoki
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
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Kashimoto Naoki
広島大学原爆放射線医科学研究所 分子発がん制御研究分野
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Kashimoto Naoki
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Kashiwabara Shoji
広島大学原爆放射能医学研究所
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Kashiwabara Shoji
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Katoh Osamu
The Division Of Cardiol Sakurabashi Watanabe Hospital
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Katoh O
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Katoh Osamu
広島大学原爆放射能医学研究所
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Uesaka T
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Uesaka Toshihiro
広島大学原爆放射能医学研究所
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Uesaka Tosihiro
広島大学原爆放射能医学研究所
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Watanabe Hiromitsu
広島大学原爆放射能医学研究所
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Watanabe H
Res. Inst. Rad. Biol. &med. Hiroshima Univ.
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Watanabe H
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
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Shiraki Kazuhisa
Graduate School Of Biomedical Science Hiroshima University
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Sugiura Kazumi
広島大学原爆放射能医学研究所
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Kin Keishi
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Katoh Osamu
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Uesaka Toshihiro
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Watanabe Hiromitsu
Dept. Environ. Mutat. Res. Inst. Forradiat. Biol. Med. Hiroshima Univ.
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Kato Osamu
Sakurabashi Watanabe Hospital And Ist. Dept. Of Med. Osaka Univ. School Of Med.
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Katoh Osamu
Department Of Cardiology Toyohashi Heart Center
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Kitamura Shigeyuki
Graduate School Of Bioagricultural Sciences Nagoya University
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