Comparison of Tumorigenesis between Accelerated Heavy Ion and X-ray in B6C3F1 Mice
スポンサーリンク
概要
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The effects of heavy ion and X-ray irradiation on tumorigenesis in B6C3F1 mice were compared. Six-week-old animals were divided into 6 groups and exposed to 0.426 Gy heavy ion irradiation of 290 MeV/u carbon-ion beam (LET 60-210 KeV/μm) at the dose rate of 0.4±0.2 Gy/min; 0.5 Gy of X-ray irradiation at 0.1 Gy/min or 5 Gy of X-ray irradiation at 1 Gy/min. The mice were killed and an autopsy performed 13.5 months after the whole body irradiation. Body weights were heaviest for both sexes in the 0.5 Gy group and lightest in the 5 Gy one. Total tumor incidences in the males were 30, 56 and 13% respectively in the heavy ion, 5 Gy and 0.5 Gy X-irradiated groups, stomach tumors, lymphomas and adrenal tumors being the most common outcome of the high dose X-rays. Liver tumor induction did not differ significantly among the groups. In the females tumorigenicity was significantly lower for heavy ion than for 0.5 Gy and 5 Gy X-ray irradiation (P<0.05), the respective incidences, mainly ovary one, being 73%, 17% and 41%. Non-cancerous lesions, such as graying of the hair, glomerular sclerosis and amyloidosis appeared in the 5 Gy group. These findings indicate that 0.426 Gy of heavy ion irradiation induced lower carcinogenicity than 5 Gy of X-irradiation and higher carcinogenicity than that of 0.5 Gy X-irradiation in male mice.
- 日本放射線影響学会の論文
著者
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WATANABE Hiromitsu
Department of Cancer Research, Hiroshima University
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Katoh Osamu
Department of Cardiology, Toyohashi Heart Center
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Takahashi Toshiaki
Department of Hypertension and Cardiorenal Disease, Dokkyo Medical University
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Katoh Osamu
The Division Of Cardiol Sakurabashi Watanabe Hospital
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Katoh O
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Katoh Osamu
広島大学原爆放射能医学研究所
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Watanabe Hiromitsu
広島大学原爆放射能医学研究所
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Watanabe H
Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima
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Shoji Shuneki
Dept. Environ. Mutat. Res. Inst. Forradiat. Biol. Med. Hiroshima Univ.
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Shoji Shuneki
広島大学原爆放射能医学研究所
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Shoji Shuneki
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine
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Sanoh Seigo
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Oguri T
Hiroshima Univ. Fac. Medicine Hiroshima
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Oguri Tetsuya
Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi
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Oguri Tetsuya
Second Department Of Internal Medicine Hiroshima University Faculty Of Medicine
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Shoji Shuneki
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Shoji Shuneki
Div. Environ. Biol. Res. Inst. Rad. Biol. And Med. Hiroshima University
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Katoh Osamu
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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OGIU Toshiaki
National Institute of Radiological Sciences
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NISHIMURA Mayumi
National Institute of Radiological Sciences
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MASAOKA Yoshiyuki
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiros
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WATANABE HJROMITSU
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiros
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KUROSUMI MASAO
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiros
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Takahashi Toshiaki
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Takahashi Tadateru
Department Of Cancer Research Division Of Envrionmental Biology Research Institute For Radiation Bio
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Watanabe Hiromitsu
Dept. Environ. Mutat. Res. Inst. Forradiat. Biol. Med. Hiroshima Univ.
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Takahashi T
Hiroshima Univ. Hiroshima Jpn
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Kato Osamu
Sakurabashi Watanabe Hospital And Ist. Dept. Of Med. Osaka Univ. School Of Med.
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Shoji Syuneki
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine
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Oguri Tetsuya
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Kurosumi Masao
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Katoh Osamu
Department Of Cardiology Toyohashi Heart Center
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Shoji Shuneki
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Masaoka Y
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Masaoka Yoshiyuki
Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi
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Takahashi T
Second Department Of Internal Medicine Hiroshima University School Of Medicine
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Takahashi Toshiaki
Second Department Of Internal Medicine Hiroshima University School Of Medicine
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Takahashi Toshiaki
Department Of Anesthesiology Tokyo Medical University
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Shoji Shuneki
Department Of Cellular Biology Division Of Radiation And Regeneration Control Research Institute For
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