Effects of Stilbene and Related Compounds on Reproductive Organs in B6C3F1/Crj Mouse
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概要
- 論文の詳細を見る
trans-Stilbene exhibits estrogenic activity in an estrogen reporter assay after metabolic activation. In this study, uterotrophic assay was conducted using ovariectomized B6C3F1/Crj female mice treated with trans-stilbene, trans-4-hydroxystilbene,trans-4,4'-dihydroxystilbene and diethylstilbestrol. Administration of trans-4-hydroxystilbene, trans-4,4'-dihydroxystilbene and diethylstilbestrol elicited increases in absolute and relative uterus weight. Further-more, the uterine response caused by the hydroxylated stilbenes was accompanied with an increase in the thickness of epithelial cell layers. frans-Stilbene itself also showed estrogenic activity, affecting uterine weight and causing histological changes of the uterus. This suggests that trans-stilbene is activated to hydroxylated metabolites to exhibit its estrogenic activity. Indeed, trans-hydroxystilbenes were detected in the urine and feces of mice dosed with trans-stilbene. The effect of stilbene derivatives on testis in newborn B6C3F1/Crj mouse was examined. Adminis-tration of diethylstilbestrol slightly decreased the testis weight and atrophy of seminiferous tubules. However, trans-stilbene and trans-4-hydroxystilbene affected neither testis weight nor the histological appearance of the testis.
- 2006-10-01
著者
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OHTA Shigeru
Graduate School of Biomedical Sciences, Hiroshima University
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Shigeyuki Kitamura
Nihon Pharmaceutical University
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Kitamura Shigeyuki
広島大学 医学部総合薬学科生体機能分子動態学
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Kitamura Shigeyuki
広島大学 総合薬
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Kitamura Shigeyuki
広島大学原爆放射能医学研究所
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KITAMURA Shigeyuki
Graduate School of Biomedical Science, Hiroshima University
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Watanabe Hiromitsu
Research Institute for Radiation Biology and Medicine, Hiroshima University
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Sanoh Seigo
Graduate School Of Biomedical Sciences Hiroshima University
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Sugihara Kazumi
Graduate School of Biomedical Sciences, Hiroshima University
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Sugihara K
Graduate School Of Biomedical Sciences Hiroshima University
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Watanabe Hiromitsu
Research Institute For Radiation Biology And Medicine Hiroshima University
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Kohta Ryuki
Graduate School of Biomedical Sciences
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Ohta S
Graduate School Of Biomedical Sciences Hiroshima University
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science. Hiroshima University School Of Medicine
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Ohta Shigeru
Graduate School Of Biomedical Sciences Hiroshima Univ.
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Kitamura Shigeyuki
Graduate School Of Bioagricultural Sciences Nagoya University
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SUGIHARA Kazumi
Graduate School of Biomedical and Health Sciences, Hiroshima University
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SANOH Seigo
Graduate School of Biomedical and Health Sciences, Hiroshima University
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