Establishment and Characterization of a Hypocatalasemic Mouse Cell Strain

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概要

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• Contact-inhibited catalase-deficient fibroblast cell strain has been established from the homozygous b hypocatalasemic C3H/Cs^b mutant mouse. This cell strain has low level of catalase enzyme activity and has normal level of enzyme activities of both glutathione peroxidase and superoxide dismutase. Catalase-deficient C3H/Cs^b mutant cell strain is markedly more sensitive to the toxicity of hydrogen peroxide compared to wild-type C3H/Cs^a cell strain. In addition, mutant cell strain is sensitive to X-rays and near-UV compared to wild-type cell strain, but shows the same sensitivities to topoisomerase II inhibitors, adriamycin and 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA), and the DNA cross-linking agents, cis-diamminedichloroplatinum (II) (cis-Pt) and trans-diamminedichloroplatinum (II) (trans-Pt). These cell strains will be of use in the study of the roles which catalase plays in the intracellular prevention of DNA damage induced by oxidative stress.

• 日本放射線影響学会の論文

著者

• Watanabe Hiromitsu

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• Tano Keizo

  Laboratory Of Radiation Life Science Research Reactor Institute Kyoto University

• UTSUMI HIROSHI

  Laboratory of Radiation Life Science, Research Reactor Institute, Kyoto University

• KODAMA SEIJI

  Laboratory of Radiation and Life Science, Department of Health Sciences, School of Pharmaceutical Sc

• HASHIMOTO MITSUMASA

  Laboratory of Radiation Life Science, Research Reactor Institute, Kyoto University

• Utsumi Hiroshi

  Laboratory Of Radiation Life Science Research Reactor Institute Kyoto University

• Hashimoto Mitsumasa

  Laboratory Of Radiation Life Science Research Reactor Institute Kyoto University

• Watanabe Hiromitsu

  Research Institute For Radiation Biology And Medicine Hiroshima University

• Kodama Seiji

  Laboratory Of Radiation And Life Science Department Of Health Sciences School Of Pharmaceutical Sciences Nagasaki University

• TANO Keizo

  Laboratory of Radiation Biology, Research Reactor Institute, Kyoto University

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