Delayed Cell Death, Giant Cell Formation and Chromosome Instability Induced by X-irradiation in Human Embryo Cells
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概要
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We studied X-ray-induced delayed cell death, delayed giant cell formation and delayed chromosome aberrations in normal human embryo cells to explore the relationship between initial radiation damage and delayed effect appeared at 14 to 55 population doubling numbers (PDNs) after X-irradiation. The delayed effect was induced in the progeny of X-ray survivors in a dose-dependent manner and recovered with increasing PDNs after X-irradiation. Delayed plating for 24 h post-irradiation reduced both acute and delayed lethal damage, suggesting that potentially lethal damage repair (PLDR) can be effective for relieving the delayed cell death. The chromosome analysis revealed that most of the dicentrics (more than 90%) observed in the progeny of X-ray survivors were not accompanied with fragments, in contrast with those observed in the first mitosis after X-irradiation. The present results indicate that the potentiality of genetic instability is determined during the repair process of initial radiation damage and suggest that the mechanism for formation of delayed chromosome aberrations by radiation might be different from that of direct radiation-induced chromosome aberrations.
- 日本放射線影響学会の論文
著者
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KODAMA SEIJI
Laboratory of Radiation and Life Science, Department of Health Sciences, School of Pharmaceutical Sc
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Kodama Seiji
Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res
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SUZUKI KEIJI
Laboratory of Radiation and Life Science, Department of Health Science, School of Pharmaceutical Sci
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Watanabe Masami
Laboratory Of Plant Nutrition Faculty Of Horticulture Chiba University
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Watanabe Masami
京都大学原子炉実験所 粒子線生物学研究分野
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Roy Kanaklata
Laboratory Of Radiation And Life Science Department Of Health Sciences School Of Pharmaceutical Scie
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Kodama Seiji
Laboratory Of Radiation And Life Science Department Of Health Sciences School Of Pharmaceutical Sciences Nagasaki University
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