Induction of Micronuclei in CHO Cells by Bleomycin but not by X-irradiation is Decreased by Treatment with HMG-CoA Reductase Inhibitors
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概要
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We investigated the effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin and fluvastation, on the induction of micronuclei by ionizing radiation or bleomycin in Chinese hamster ovary cells in order to assess the radical-scavenging ability of these inhibitors. The results indicated that both pravastatin and fluvastatin had no effect on the induction of micronuclei by X-irradiation when they were applied for either pre-treatment or post-treatment. In contrast, both drugs effectively reduced the frequency of bleomycin-induced micronuclei when they were applied for simultaneous treatment or post-treatment, but not for pre-treatment. This indicates that the radical-scavenging ability of these two HMG-CoA reductase inhibitors differs according to the origins of the radicals - e.g., X-rays or bleomycin - even when the two drugs are compared at an equivalent cytotoxic dose. Our results suggest that both pravastatin and fluvastatin have the ability to scavenge certain types of radicals and to protect cells against oxidative stress.
- 日本放射線影響学会の論文
- 2005-06-30
著者
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中島 幹夫
佐賀大学医学部附属病院 手術部
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中島 幹夫
佐賀医科大学手術部
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Suzuki Keiji
Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive
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Suzuki Keiji
大阪府立大学先端科学イノベーションセンター 放射線生命科学
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Kodama Seiji
京都大学原子炉実験所 粒子線生物学研究分野
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Kodama Seiji
長崎大学 医歯薬学総合研究科放射線生物学
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Watanabe Masami
Particle Radiation Biology Research Reactor Institute Kyoto University
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NAKASHIMA Mikiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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SASAKI Hitoshi
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Nakashima M
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima M
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Nakashima Mikiro
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Sasaki H
Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital
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Nakano M
Department Of Laboratory Medicine Nagasaki University School Of Medicine
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WATANABE Masami
Laboratory of Radiation Biology, Division of Radiation Life Science, Department of Radiation Life Sc
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Kodama S
Radiation Biology Laboratory Radiation Research Center Frontier Science Innovation Center Organizati
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Kodama Seiji
Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res
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Sasaki Hitoshi
長崎大学 医歯学部病院薬剤部
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Shiota H
Nagasaki Univ. Nagasaki Jpn
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Watanabe Masani
National Institute Of Basic Biology (nibb)
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Watanabe Masami
Laboratory Of Plant Nutrition Faculty Of Horticulture Chiba University
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Sasaki Hajime
Semiconductor Group Mitsubishi Electric Corporation
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IWASHITA Junji
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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TANIYAMA Kotaro
Department of Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University
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Watanabe Masami
京都大学原子炉実験所 粒子線生物学研究分野
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Sasaki Hideyuki
R&d Center Toshiba Corp.
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Suzuki K
Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive
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Sasaki H
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Sasaki H
Electrotechnical Laboratory
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Watanabe M
Particle Radiation Biology Research Reactor Institute Kyoto University
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Kasai Soko
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
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Kasai Soko
Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima
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Iwashita Junji
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Watanabe Masani
Division Of Radiation Biology Faculty Of Pharmacology Of Science Nagasaki University
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Suzuki K
Division Of Radiation Biology Department Of Radiology And Radiation Biology Course Of Life Sciences
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Kasai Soko
Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive
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Watanabe Masami
Lab. Of Radiation Biology Div. Of Radiation Life Sci. Res. Reactor Inst. Kyoto Univ.
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Sasaki H
Nagasaki Univ. School Of Medicine Nagasaki Jpn
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Taniyama Kotaro
Department Of Pharmacology Graduate School Of Biomedical Sciences Nagasaki University
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Sasaki Hitoshi
Department Of Hospital Pharmacy Nagasaki University Hospital
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Nakashima Mikiro
Department of Clinical Pharmacy, Graduate School of Biomedical Sciences, Nagasaki University
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Taniyama Kotaro
Department of Pharmacology 2, Nagasaki University School of Medicine
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