Characterization of Ocular Pharmacokinetics of Tilisolol after Instillation into Anesthetized Rabbits
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概要
- 論文の詳細を見る
The purpose of this study was to characterize the ocular pharmacokinetics of a beta-blocker, tilisolol, after instillation into anesthetized rabbits using a mathematical model including a diffusion process. The samples were analyzed by HPLC. Anesthetized rabbit was used as a model of tear secretion deficiency. Anesthetized rabbits showed higher drug concentration in the tear fluid and aqueous humor after instillation than unanesthetized rabbits. A mathematical model including a diffusion process and in vivo penetration parameters well described the concentrations of tilisolol in the aqueous humor after instillation in anesthetized rabbits.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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中島 幹夫
佐賀大学医学部附属病院 手術部
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Murakami T
Kyoto Univ. Kyoto
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NAKASHIMA Mikiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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SASAKI Hitoshi
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Junzo
長崎大学 薬
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Nakamura Junzo
School Of Pharmaceutical Sciences Nagasaki University
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Nishida K
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima M
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima Mikiro
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Murakami T
National Inst. Advanced Industrial Sci. And Technol. Ibaraki
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Sasaki H
Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital
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Tomonari Masahide
参天製薬奈良研究開発センター
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Mukai T
九州大学 大学院薬学研究院
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Mukai Takahiro
Graduate School Of Pharmaceutical Sciences Kyushu University
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Mukai Takahiro
京都大学 薬学研究科病態機能分析学
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Mukai Takahiro
Graduate School Of Medicine Kyoto University
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ICHIKAWA Masataka
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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Nakano M
Department Of Laboratory Medicine Nagasaki University School Of Medicine
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Ichikawa M
Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.
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Mori Tomohiko
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Sasaki Hitoshi
長崎大学 医歯学部病院薬剤部
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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NISHIDA Koyo
School of Pharmaceutical Sciences, Nagasaki University
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MUKAI Takahiro
School of Pharmaceutical Sciences, Nagasaki University
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YAMAMURA Kenzo
School of Pharmaceutical Sciences, Nagasaki University
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Yamamura Kenzo
School Of Pharmaceutical Sciences Nagasaki University
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Mukuno Takashi
The Graduate School Of National Science And Technology Okayama University
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Ichikawa Masataka
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Ichikawa Masataka
Department Of Pharmacy Nagasaki University Hospital
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ICHIKAWA MASATAKA
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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Nakashima Mikiro
Department of Clinical Pharmacy, Graduate School of Biomedical Sciences, Nagasaki University
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ICHIKAWA MASATAKA
Department of Chemical Engineering, Kyushu University
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