Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs

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概要

• 論文の詳細を見る

• Methods to predict the responsiveness of a particular tumor to a particular anticancer drug are desirable not only for chemotherapy but also for chemoradiotherapy. Here, we examined the effects of viral or activated oncogenes on sensitivity to anticancer drugs by using SHOK (Syrian hamster Osaka-Kanazawa) cells and their transfectants. The IC_<50> of each transfectant was compared with that of the pSV2Neo transfected control. Cells transfected with the c-myc, v-mos, or v-fgr gene increased their sensitivity to bleomycin, while those transfected with the H-ras gene developed resistance. Resistance to cisplatin was conferred by the introduction of the H-ras or c-cot gene. In the case of adriamycin, the c-myc or c-cot transfectant increased sensitivity and the H-ras transfectant decreased it. Mitomycin C resistance was observed by the introduction of the K-ras gene. Thus, the H-ras gene was found to be involved in the development of resistance to three of the four anticancer drugs. In addition, we have for the first time shown that mos and cot have an effect on sensitivity to three and all of the four anticancer drugs, respectively. These results suggest that the expression of each oncogene would differently affect sensitivity to the four anticancer drugs used in this study, and this property could be a possible marker to predict chemosensitivity.

• 日本放射線影響学会の論文
• 2005-06-30

著者

• Suzuki Keiji

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• Suzuki Keiji

  Division Of Radiation Biology Department Of Radiology And Radiation Biology Graduate School Of Biome

• Kodama Seiji

  京都大学原子炉実験所 粒子線生物学研究分野

• Kodama Seiji

  長崎大学 医歯薬学総合研究科放射線生物学

• Watanabe Masami

  Particle Radiation Biology Research Reactor Institute Kyoto University

• SASAKI Hitoshi

  Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry

• Sasaki H

  Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital

• ICHIKAWA Masataka

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Kodama S

  Radiation Biology Laboratory Radiation Research Center Frontier Science Innovation Center Organizati

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Sasaki Hitoshi

  長崎大学 医歯学部病院薬剤部

• Sasaki Hitoshi

  Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University

• Shiota H

  Nagasaki Univ. Nagasaki Jpn

• Watanabe Masami

  Radiation life science, pharm, Nagasaki-Univ.

• HAMAMOTO Tomoyuki

  Department of Hospital Pharmacy, Nagasaki University School of Medicine

• Watanabe Masani

  National Institute Of Basic Biology (nibb)

• Sasaki Hajime

  Semiconductor Group Mitsubishi Electric Corporation

• Watanabe Masami

  京都大学原子炉実験所 粒子線生物学研究分野

• Sasaki Hideyuki

  R&d Center Toshiba Corp.

• Hamamoto Tomoyuki

  Department Of Hospital Pharmacy Nagasaki University School Of Medicine

• Sasaki H

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Sasaki H

  Electrotechnical Laboratory

• Watanabe M

  Particle Radiation Biology Research Reactor Institute Kyoto University

• Kasai Soko

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kasai Soko

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Watanabe Masani

  Division Of Radiation Biology Faculty Of Pharmacology Of Science Nagasaki University

• Suzuki K

  Division Of Radiation Biology Department Of Radiology And Radiation Biology Course Of Life Sciences

• Kasai Soko

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Watanabe Masami

  Lab. Of Radiation Biology Div. Of Radiation Life Sci. Res. Reactor Inst. Kyoto Univ.

• Sasaki H

  Nagasaki Univ. School Of Medicine Nagasaki Jpn

• Ichikawa Masataka

  Department Of Hospital Pharmacy Nagasaki University School Of Medicine

• Suzuki Keiji

  Division Of Applied Biology Faculty Of Textile Science And Technology Shinshu University

• Sasaki Hitoshi

  Department Of Hospital Pharmacy Nagasaki University Hospital

• ICHIKAWA MASATAKA

  Department of Hospital Pharmacy, Nagasaki University School of Medicine

• ICHIKAWA MASATAKA

  Department of Chemical Engineering, Kyushu University

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