Induction of Gene Mutation and Cancer by Extra-DNA Bystander Effect of Long-lived Protein Radicals inGamma Ray Irradiated Mammalian Cells.

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概要

• 論文の詳細を見る
• 日本放射線影響学会の論文

著者

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Kodama Seiji

  Lab. Radiat. &life Sci. Schl. Pharm. Sci. Nagasaki Univ.

• WATANABE Masami

  Lab. Radiat. and Life Sci., Schl. Pharm. Sci., Nagasaki Univ.

• Miyazaki Tetsuro

  Appl. Chem. Grad. Sch. Eng. Nagoya Univ.

• Miyazaki Tetsuo

  Dept. Applied Chem. Nagoya Univ.

• Watanabe Masami

  京都大学原子炉実験所 粒子線生物学研究分野

• Kumagai Jun

  Applied Chem. Grad. Sch. Eng. Nagoya Univ.

• Masui Kiyonao

  Appl. Chem. Grad. Sch. Eng. Nagoya Univ.

• Watanabe Masani

  Division Of Radiation Biology Faculty Of Pharmacology Of Science Nagasaki University

• Suzuki K

  Division Of Radiation Biology Department Of Radiology And Radiation Biology Course Of Life Sciences

• Watanabe Masami

  Lab. Of Radiation Biology Div. Of Radiation Life Sci. Res. Reactor Inst. Kyoto Univ.

• Shiotani Masaru

  Appl. Chem. Grad. Sch. Eng. Hiroshima Univ.

• MIYAZAKI Tetsuo

  Appl. Chem. Grad. Sch. Eng. Nagoya Univ.

• ITAGAKI Yoshiteru

  Appl. Chem. Grad. Sch. Eng. Hiroshima Univ.

• KUMAGAI Jun

  Appl. Chem. Grad. Sch. Eng. Nagoya Univ.

関連論文

• Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration
• Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo-chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells
• Potentially Lethal Damage Repair by Total and Quiescent Tumor Cells Following Various DNA-damaging Treatments
• Enhancement of Cisplatin Sensitivity of Quiescent Cells in Solid Tumors by Combined Treatment with Tirapazamine and Low-Temperature Hyperthermia
• Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells
• Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo
• Absence of G1 arrest after X-ray irradiation in cancer cells with wild-type p53
• Biological effect of radiation-induced long life radicals
• Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation : Comparison with γ-Ray Radiation
• Repair of Skin Damage During Fractionated Irradiation with Gamma Rays and Low-LET Carbon Ions
• Biological Gain of Carbon-ion Radiotherapy for the Early Response of Tumor Growth Delay and against Early Response of Skin Reaction in Mice
• 269 Significance of beta term in carbon-ion radiotherapy(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 265 Relationship between RBE values of Carbon Ion and Tumor Growth Rate(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Radioprotective Effects of Beer on Radiation-Induced Acute Toxicity in Mice
• Dependence of Gut-crypt Sensitivity on the Time Interval between Two Fractions of Carbon Ion Radiation
• Tumor Growth Rate and RBE values of high LET Carbon Ions
• Dependence of Carbon-Ion RBE on Dose Size -Difference between Skin and Tumors
• Relative Biological Effectiveness of 290 MeV/u Carbon Ions for the Growth Delay of a Radioresistant Murine Fibrosarcoma
• RBE of Carbon Ions for Tumor Growth Delay
• Fractionated irradiation with carbon ions induced resistance in mouse gut crypt cells
• Relative Biological Effectiveness of the 235 MeV Proton Beams at the National Cancer Center Hospital East
• Effects of sequentially mixed LET on tumor growth delay
• Fractionated irradiation with carbon ions to gut intestinal crypt cells
• Tumor Induction in Mice Locally Irradiated with Carbon Ions : A Retrospective Analysis
• Introduction of a Normal Human Chromosome 8 Corrects Abnormal Phenotypes of Werner Syndrome Cells Immortalized by Expressing an hTERT Gene
• Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation
• 226 Radiation-induced delayed chromosomal instability caused by large deletion(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 223 Radiation-Induced Delayed Chromosomal Instability(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 221 A Role of DNA Double Strand Break Repair in the Induction of Genetic Instability(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 214 The complementation of abnormal phenotypes of Werner syndrome cells by expressing WRN gene(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• S-2-3 Radiation-Induced Delayed Chromosome Aberrations(Radiation Induced Genetical Instability : What Is the Mechanism That a Cell Memorizes Being Irradiated?, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Instability of a Human Chromosome Exposed to Radiation in Unirradiated Mouse Cells
• The Role of DNA-PKcs Function on Induction of Genetic Instability by Radiation
• Radiation-induced genomic instability caused by large deletion (position)
• Thermosensitization by Inhibition of Gap Junctional Intercellular Communication
• Phenotypic Reversion of an X-Ray-Induced Transformant of Mouse m5S by Introduction of a Human Chromosome 11
• The Effect of DNA Repair Defects on the Induction of Delayed Chromosome Aberrations by Radiation
• Involvement of Telonomic Instability in the Formation of Delayed Chromosome Aberrations Induced by Radiation
• Tumor Vasculature and PO2 Distributions Depend on Implantation Site
• Morphometric Evaluation of Late Normal Tissue Damage after Neon Beam Irradiation in Mouse Hind Legs
• Effects of fractionated irradiation with carbon ions on the NFSa fibrosarcoma in mice
• Adjuvant Radiation Therapy Following Mastectomy for Breast Cancer
• Evidence for Induction of DNA Double Strand Breaks in the Bystander Response to Targeted Soft X-Rays in Repair Deficient CHO Cells
• Apoptosis Induction in the NFSa tumor after irradiation with carbon ions
• Increased Chromosome Instability and Accumulation of DNA Double-strand Breaks in Werner Syndrome Cells
• Biochemical Markers for in Situ Detection of DNA Double Strand Breaks in Cultured Mammalian Cells
• Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages
• Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
• Involvement of Reactive Oxygen Species (ROS) in the Induction of Genetic Instability by Radiation
• 225 Influence of Reactive Oxygen Species in the Induction of Genetic Instability by Radiation(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 222 X-ray-induced genomic instability in Atm knock-out mouse cells(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 220 Mechanism of radiation-induced delayed mutagenesis(Genetic instability, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 217 Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 168 Mechanism of cell cycle-dependent cell death by heat shock(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 141 The role of site-specific phosphorylation on X-ray-induced p53 accumulation(Redox regulation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Response of Mouse Intestine to Carbon-12 Beams in Relation to Dose Fraction and Effects of Steroids on Radiation-Induced Intestinal Damages
• 104 DNA Damage-Induced Phosphorylation of Histone H2AX and Alteration of Chromatin Structure(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 97 A Role of WRN Protein in the Recovery from DNA Replication Arrest(Repair of radiation damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Induction of Micronuclei in CHO Cells by Bleomycin but not by X-irradiation is Decreased by Treatment with HMG-CoA Reductase Inhibitors
• Involvement of reactive oxygen species (ROS) in the induction of genetic instability by radiation
• Relationship between dysfunction of WRN protein and radiosensitivity
• Role of WRN exonuclease in repair of DNA double strand breaks
• Characterization of X-ray-induced Mutation in Werner Syndrome Cells
• Analysis of X-Ray-Induced Mutation in Werner Syndrome Cells
• Differences in pO_2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation
• 267 Early Change of ^C-Thymidine Uptake after Carbon-beam Irradiation in Experimental Tumors(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Enhancement of the relative uptake of F-FDG in mouse fibrosarcoma by rolipram
• Tumor induction in mouse legs after irradiation with heavy ions
• Phosphorylated ATM Foci as a Biochemical Marker for DNA Double Strand Breaks
• Mechanism of radiation-induced delayed mutagenesis
• Delayed Induction of DNA Damage and Activation of p53 in X-ray Surviving Cells
• Participation of ATM function in X-ray-induced delayed chromosomal instability
• Biological Action of Curcumin on Transformed Mouse Cells
• Biological Action of Curcumin on Transformed Mouse Cells
• Role of Ser15, Thr18, and Ser20 phosphorylation in p53 stabilization after X-irradiation
• X-rays-induced phosphorylation of H2AX in mitotic cells
• The role of telomerase activity in the radiation carcinogenesis processes of normal human cells
• Suppressive Effect of p53 on Heat-induced Multiple Centrosomes
• In vitro transformation system using hTERT-transfected normal human diploid cells
• Radiation-induced delayed damage in scid mouse cells
• Mechanism of p53 Accumulation and Activation by Ionizing Radiation and Telomere Shortening
• Recovery of clonogenic tumor cells after irradiation with carbon ions
• 211 Effect of RibCys on scavenging long-lived radicals and reducing gene mutation in mammalian cells by adding AFTER irradiation(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Inhibitory Effect of Curcumin on the Growth of Transformed Mouse Cells
• Involvement of Long-Lived Radicals Induced by Radiation in the Induction of Mutation
• Suppression of Radiation-Induced Mutation by an Anti-Oxidant Material
• Induction of Gene Mutation and Cancer by Extra-DNA Bystander Effect of Long-lived Protein Radicals inGamma Ray Irradiated Mammalian Cells.
• Scavenging of long-lived radicals by (?)-epigallocatechin-3-O-gallate and simultaneous suppression of mutationin irradiated mammalian cells
• Direct Observation of Long-lived Radicals in Irradiated Mammalian Cells which Cause Mutation
• S-6-2 Long-Lived Radicals (LLR) Causes Genotoxic Effects(Biological Effects of Long-lived Radicals Induced by Radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Mechanism of delayed mutagenesis by radiation-induced genomic instability
• Enhanced Cell Proliferation by X-Irradiated Conditioned Medium
• Dose-dependent bi-phasic accumulation of p53 protein in normal human embryo cells following X-irradiation
• Radiation-Induced Genetic Instability in Scid Mouse Cells
• Radiation-Induced Delayed Chromosome Instability Studied by a Microcell-Mediated Chromosome Transfer
• Defective Accumulation of p53 Protein In X-irradiated Human Tumor Cells With Low Proteasome Activity
• Abnormal Radiosensitivity at G2 Phase in Werner Syndrome Cells and Its Complementation by Introduction of a Normal Human Chromosome 8
• X-ray-induced delayed damage in normal human embryo cells
• Activation of p53 suppresses mitotic catastrophe in response to ionizing radiation
• Increase of heat sensitivity by the induction of HSP72 with deletion of its ATP-binding domain

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