Relative Biological Effectiveness of the 235 MeV Proton Beams at the National Cancer Center Hospital East

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概要

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• A therapy-dedicated cyclotron was installed in the National Cancer Center Hospital East (NCCHE) at Kashiwa in 1997. Prior to the start of clinical use, we investigated the biological effectiveness of therapeutic proton beams for cell lethality. The proton beams accelerated up to 235 MeV were horizontally extracted from the cyclotron, and scattered by a bar-ridge filter to produce a Spread-Out-Bragg-Peak (SOBP) of 10-cm width. The biological systems used here were mouse intestinal crypt cells and three in vitro cell lines, including SCC61 human squamous cell carcinoma, NB1RGB human fibroblasts and V79 Chinese hamster cells. The dose responses after irradiation at either the entrance plateau or the middle portion of SOBP were compared with those after linac 6 MV X-ray irradiation. The fit of a linear quadratic model to survival curves showed that proton irradiation increased the α value of SCC61 and the β value of V79 cells with a least change for α/ β ratio of NB1RGB cells. The isoeffect dose that reduces either cell survivals to 10% or mouse jejunum crypts to 10 per circumference was termed D_10. The relative biological effectiveness (RBE) of protons obtained by comparing the D_10 values between protons and X-rays ranged from 0.9 to 1.2. The depth distribution of cell lethality was measured by replating V79 cells after irradiation from a "cell stack chamber" that received a single dose of 7 Gy at the middle position of SOBP. The thus-obtained cell survivals at various depths coincided well with the estimated survivals, but tended to decrease at the distal end of SOBP . We conclude that an RBE of 1.1 would be appropriate for 235 MeV proton beams at the NCCHE.

• 日本放射線影響学会の論文

著者

• IKEDA Hiroshi

  Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• Suzuki Minoru

  Particle Radiation Oncology Research Center Kyoto University

• 安藤 興一

  学振科技特

• Suzuki M

  Particle Radiation Oncology Research Center Kyoto University

• OGINO Takashi

  Department of Radiology, National Cancer Center Hospital Ease

• FURUSAWA Yoshiya

  National Institute of Radiological Sciences

• Futami Yasuyuki

  茨城県立医療大学 放射線技術科学科

• Futami Yasuyuki

  Division Of Accelerator Physics And Engineering National Institute Of Radiological

• Futami Yasuyuki

  The Institute Of Physics University Of Tsukuba

• Futami Yasuyuki

  Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa

• Ikeda Hiroshi

  Department Of Radiation Oncology National Cancer Center Hospital East

• Sasai Keisuke

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Nojima K

  National Inst. Radiological Sci. Chiba Jpn

• Ogino Takashi

  Department Of Radiation Oncology National Cancer Center Hospital East

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital

• Sasai Keisuke

  京都大学 放射腺腫瘍学･画像応用療学

• Aoki M

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Aoki Mizuho

  Clinical Radiation Biology and International Space Radiation Laboratory,National Institute of Radiol

• Furusawa Yoshiya

  Clinical Radiation Biology and International Space Radiation Laboratory,National Institute of Radiol

• Ando Koichi

  Clinical Radiation Biology and International Space Radiation Laboratory,National Institute of Radiol

• SUZUKI MASAO

  Clinical Radiation Biology and International Space Radiation Laboratory

• NOJIMA KUMIE

  Clinical Radiation Biology and International Space Radiation Laboratory

• MAJIMA HIDEYUKI

  Clinical Radiation Biology and International Space Radiation Laboratory

• KOIKE SACHIKO

  Clinical Radiation Biology and International Space Radiation Laboratory

• SHIMIZU WAKAKO

  Clinical Radiation Biology and International Space Radiation Laboratory

• MURAYAMA SHIGEYUKI

  Department of Radiation Oncology, National Cancer Center Hospital East

• KOIKE Sachiko

  National Inst. of Radiol. Sci

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Ando Koichi

  Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences

• Suzuki Masao

  Heavy-ion Radiobiology Res. Group National Inst. Radiological Sciences

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Murayama Shigeyuki

  Department Of Materials Science And Engineering

• Murayama Shigeyuki

  Department Of Radiation Oncology National Cancer Center Hospital East

• Itsukaichi Hiromi

  Radiation Hazards Research Groupe Natl. Inst. Radiat Sci.

• Majima H

  The Institute Of Industrial Science The University Of Tokyo

• Furusawa Yoshiya

  高エネルギー加速器研究機構物質構造科学研究所

• Nojima Kumie

  International Space Radiation Laboratory National Institute Of Radiological Sciences

• Koike Sachiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Shimizu Wakako

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Majima Hideyuki

  International Space Radiation Laboratory National Institute Of Radiological Sciences

• Majima Hideyuki

  Department Of Oncology Maxillofocal Radiology Division And Department Of Space Environmental Medicin

• Ando Koichi

  Clinical Radiation Biology And International Space Radiation Laboratory National Institute Of Radiol

• Ogino Takashi

  Department Of Mechanical Engineering Tsuruoka National College Of Technology

• Ikeda Hiroshi

  Department Of Gastroenterology & Hepatology Okayama University Graduate School Of Medicine Denti

• Ikeda Hiroshi

  Department Of Applied Chemistry Graduate School Of Engineering Osaka Prefecture University

• IKEDA HIROSHI

  Deparment of Biology, Faculty of Science, Tokyo Metropolitan University

• Ogino Takashi

  Department of Emergency Medicine, Gunma University, Graduate School of Medicine

• Ogino Takashi

  Department of Chemistry, Faculty of Science, The University of Tokyo

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