Differences in pO_2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation

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• We measured and compared the oxygen partial pressure (pO_2) profiles in experimental tumors after irradiation with carbon ions and with X-rays. The NFSa fibrosarcomas grown in the hind legs of C3H male mice received isoeffect single doses of carbon ions or X-rays. Coaxial oxygen microelectrodes of high spatial resolution were inserted into the tumor with 20 μm steps by a computerized micromanipulator. The number of pO_2 peaks that reached 15mmHg were at least 0.45 per 3,000μm in unirradiated tumors and significantly increased to 1.55 per 3,000 μm as early as day 1 of carbon-ion irradiation (p<0.001). The tumors that received X-ray irradiation also significantly increased pO_2 peaks, but as late as day 3. The time course of pO_2 peak appearance in the present study coincides with a previous report where reoxygenation was measured by paired growth delay assay. The pO_2 peaks appeared selectively in peripheral regions of X-ray irradiated tumors, but they appeared rather homogeneously in the tumor after carbon-ion irradiation. It is concluded that carbon-ion irradiation reoxygenated the NFSa fibrosarcomas earlier in time and deeper in space than the X-ray irradiation did.

• 2004-06-15

著者

• 安藤 興一

  放医研

• Suzuki Keiji

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• 安藤 興一

  学振科技特

• 安藤 興一

  Natl. Instit. Rad. Sci. Med.

• 小池 幸子

  北里大学 獣医学部

• Sasai Keisuke

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Ando K

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Kodama S

  Radiation Biology Laboratory Radiation Research Center Frontier Science Innovation Center Organizati

• Ando Koichi

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital

• Sasai Keisuke

  京都大学 放射腺腫瘍学･画像応用療学

• Kobayashi Hirosuke

  Department of Medicine, Kitasato University

• KOIKE Sachiko

  National Inst. of Radiol. Sci

• Ando Soichiro

  National Institute Of Radiological Sciences

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Ando Koichi

  Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences

• Koike Sachiko

  Research Center For Charged Particle Therapy Natl. Inst. Radiol. Sci.

• ANDO Koichi

  Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences

• OKA Kotaro

  Institute of Biomedical Engineering, Faculty of Science and Technology, Keio University

• TANISHITA Kazuo

  Institute of Biomedical Engineering, Faculty of Science and Technology, Keio University

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Fukawa Takeshi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• KOIKE SACHIKO

  Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences

• Sasai Keisuke

  Department Of Radilogy And Nuclear Medicine Faculty Of Medicine Kyoto University

• Fukawa Takeshi

  放射線医学総合研究所

• Oka K

  Dept. Of Biosciences And Informatics Fac. Of Sci. And Tech. Keio Univ.

• Oka Kotaro

  慶応義塾大学 生命情報工学

• Oka Kotaro

  Institute Of Biomedical Engineering Keio University:department Of System Design Engineering Keio Uni

• Kasai Soko

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kasai Soko

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Koike Sachiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• FUKAWA Takeshi

  Institute of Biomedical Engineering, Keio University

• TAKEMATSU Koji

  Department of System Design Engineering, Keio University

• Takematsu Koji

  Department Of System Design Engineering Keio University

• Tanishita Kazuo

  Institute Of Biomedical Engineering Keio University:department Of System Design Engineering Keio Uni

• Tanishita Kazuo

  Institute Of Biomedical Engineering Keio University

• Tanishita Kazuo

  Lnst. Biomedical Engineering Keio Univ.

• Kobayashi Hirosuke

  Department Of Respiratory Medicine Kitasato University School Of Medicine

• Kobayashi Hirosuke

  Department Of Clinical Engineering Kitasato University Of Allied Health Sciences

• Tanishita Kazuo

  Institute Of Biomedical Engineering Faculty Of Science And Technology Keio University

• Ando Koichi

  International Space Radiation Laboratory National Institute Of Radiological Sciences

• Fukawa Takeshi

  慶応義塾大学

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