Relative Biological Effectiveness of 290 MeV/u Carbon Ions for the Growth Delay of a Radioresistant Murine Fibrosarcoma

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概要

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• The relative biological effectiveness (RBE) for animal tumors treated with fractionated doses of 290 MeV/u carbon ions was studied. The growth delay of NFSa fibrosarcoma in mice was investigated following various daily doses given with carbon ions or those given with cesium γ-rays, and the RBE was determined. Animal tumors were irradiated with carbon ions of various LET (linear energy transfer) in a 6-cm SOBP (spread-out Bragg peak), and the isoeffect doses; i.e. the dose necessary to induce a tumor growth delay of 15 days were studied. The isoeffect dose for carbon ions of 14 and 20 keV/μm increased with an increase in the number of fractions up to 4 fractions. The increase in the isoeffect dose with the fraction number was small for carbon ions of 44 keV/μm, and was not observed for 74 keV/μm. The α and β values of the linear-quadratic model for the radiation dose-cell survival relationship were calculated by the Fe-plot analysis method. The α values increased linearly with an increase in the LET, while the β values were independent of the LET. The α/β ratio was 129±10 Gy for γ-rays, and increased with an increase in the LET, reaching 475±168 Gy for 74 keV/μm carbon ions. The RBE for carbon ions relative to Cs-137 γ-rays increased with the LET. The RBE values for 14 and 20 keV/μm carbon ions were 1.4 and independent of the number of fractions, while those for 44 and 74 keV/μm increased from 1.8 to 2.3 and from 2.4 to 3.0, respectively, when the number of fractions increased from 1 to 4. Increasing the number of fractions further from 4 to 6 was not associated with an increase in the RBE. These results together with our earlier study on the skin reaction support the use of an RBE of 3. 0 in clinical trials of 80 keV/μm carbon beams. The RBE values for low doses of carbon beams were also considered.

• 日本放射線影響学会の論文

著者

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• 山田 滋

  放医研・重粒子医科学センター

• FURUSAWA Yoshiya

  Heavy-ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• 安藤 興一

  学振科技特

• 安藤 興一

  放射線医学総合研究所重粒子医科学センター粒子線生物研究グループ

• 安藤 興一

  Natl. Instit. Rad. Sci. Med.

• FURUSAWA Yoshiya

  National Institute of Radiological Sciences

• FUTAMI Yasuyuki

  Shizuoka Cancer Center

• Futami Yasuyuki

  茨城県立医療大学 放射線技術科学科

• Futami Yasuyuki

  The Institute Of Physics University Of Tsukuba

• Futami Yasuyuki

  Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa

• Ando Koichi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• TAKAI Nobuhiko

  Heavy-ion Radiobio. Res. Grp., Natl Inst. Radiol. Sci.

• Sasai Keisuke

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• OOHIRA Chisa

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• KOIKE Sachiko

  Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• Ando K

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Ando Koichi

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Nojima K

  National Inst. Radiological Sci. Chiba Jpn

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital

• Koike Sachiko

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Sasai Keisuke

  京都大学 放射腺腫瘍学･画像応用療学

• Monobe Manami

  Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Monobe M

  Chiba Univ. Chiba Jpn

• Takai Nobuhiko

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• NOJIMA Kumie

  International Space Radiation Laboratory

• Aoki M

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• AOKI Mizuho

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• FUKAWA Takeshi

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• MONOBE Manami

  Heavy-ion Radiobiology Research Group, Natl. Inst. Radiol. Sci.

• LEE RYONFA

  RadGenomics Project, National Institute of Radiological Sciences

• YAMADA SHIGERU

  Hospital, National Institute of Radiological Sciences

• SHIMIZU WAKAKO

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• MAJIMA HIDEYUKI

  International Space Radiation Laboratory, National Institute of Radiological Sciences

• Nojima Kumie

  International Space And Radiation Laboratory National Institute Of Radiological Sciences

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Monobe Manami

  Tokyo Univ. Sci. Chiba Japan

• Lee Ryonfa

  放射線医学総合研究所

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Fukawa Takeshi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Oohira Chisa

  放射線医学総合研究所

• Oohira Chisa

  Radgenomics Project National Institute Of Radiological Sciences

• Ohira Chisa

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Majima H

  The Institute Of Industrial Science The University Of Tokyo

• Sasai Keisuke

  Department Of Radilogy And Nuclear Medicine Faculty Of Medicine Kyoto University

• Fukawa Takeshi

  放射線医学総合研究所

• Aoki Mizuho

  Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.

• Koike Sachiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Shimizu Wakako

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Takai Nobuhiko

  Department Of Molecular And Cellular Pharmacology Nagoya City University

• Lee Ryonfa

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Majima Hideyuki

  International Space Radiation Laboratory National Institute Of Radiological Sciences

• Furusawa Yoshiya

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Ando Koichi

  Heavy-ion Radio. Res. Nirs

• Furusawa Yoshiya

  Heavy-ion Radiobiol. Res. Gr. Res. Center Charged Particle Therapy Nirs.

• Fukawa Takeshi

  慶応義塾大学

• ANDO KOICHI

  International Space and Radiation Laboratory, National Institute of Radiological Sciences

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