Repair of Skin Damage During Fractionated Irradiation with Gamma Rays and Low-LET Carbon Ions

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概要

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• In clinical use of carbon-ion beams, a deep-seated tumor is irradiated with a Spread-Out Bragg peak (SOBP) with a high-LET feature, whereas surface skin is irradiated with an entrance plateau, the LET of which is lower than that of the peak. The repair kinetics of murine skin damage caused by an entrance plateau of carbon ions was compared with that caused by photons using a scheme of daily fractionated doses followed by a top-up dose. Right hind legs received local irradiations with either 20 keV/μm carbon ions or γ rays. The skin reaction of the irradiated legs was scored every other day up to Day 35 using a scoring scale that consisted of 10 steps, ranging from 0.5 to 5.0. An isoeffect dose to produce a skin reaction score of 3.0 was used to obtain a total dose and a top-up dose for each fractionation. Dependence on a preceding dose and on the time interval of a top-up dose was examined using γ rays. For fractionated γ rays, the total dose linearly increased while the top-up dose linearly decreased with an increase in the number of fractions. The magnitude of damage repair depended on the size of dose per fraction, and was larger for 5.2 Gy than 12.5 Gy. The total dose of carbon ions with 5.2 Gy per fraction did not change till 2 fractions, but abruptly increased at the 3rd fraction. Factors such as rapid repopulation, induced repair and cell cycle synchronization are possible explanations for the abrupt increase. As an abrupt increase/decrease of normal tissue damage could be caused by changing the number of fractions in carbon-ion radiotherapy, we conclude that, unlike photon therapy, skin damage should be carefully studied when the number of fractions is changed in new clinical trials.

• 日本放射線影響学会の論文
• 2006-06-30

著者

• 安藤 興一

  放医研

• Suzuki Keiji

  Course Of Life Sciences And Radiation Research Graduate School Of Biomedical Sciences Nagasaki Unive

• Suzuki Keiji

  大阪府立大学先端科学イノベーションセンター 放射線生命科学

• FURUSAWA Yoshiya

  Heavy-ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• 安藤 興一

  学振科技特

• 安藤 興一

  Natl. Instit. Rad. Sci. Med.

• FURUSAWA Yoshiya

  National Institute of Radiological Sciences

• FUTAMI Yasuyuki

  Shizuoka Cancer Center

• Futami Yasuyuki

  茨城県立医療大学 放射線技術科学科

• Futami Yasuyuki

  The Institute Of Physics University Of Tsukuba

• Futami Yasuyuki

  Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa

• Ando Koichi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• 笹井 啓資

  新潟大学医学部放射線医学講座

• 小池 幸子

  北里大学 獣医学部

• TAKAI Nobuhiko

  Heavy-ion Radiobio. Res. Grp., Natl Inst. Radiol. Sci.

• Sasai Keisuke

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• UZAWA Akiko

  Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• HIRAYAMA Ryoichi

  Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• KOIKE Sachiko

  Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• Ando K

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Kodama S

  Radiation Biology Laboratory Radiation Research Center Frontier Science Innovation Center Organizati

• Ando Koichi

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Kodama Seiji

  Division Of Radiation Biology And Health Science Research Center For Radiation And Radioisotopes Res

• Shibuya Keiko

  Department Of Radiation Oncology And Image-applied Therapy Kyoto University Hospital

• Koike Sachiko

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Sasai Keisuke

  京都大学 放射腺腫瘍学･画像応用療学

• Takai Nobuhiko

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Uzawa Akiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Aoki M

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• AOKI Mizuho

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• FUKAWA Takeshi

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• KOIKE Sachiko

  National Inst. of Radiol. Sci

• Ando Soichiro

  National Institute Of Radiological Sciences

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Ando Koichi

  Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences

• Koike Sachiko

  Research Center For Charged Particle Therapy Natl. Inst. Radiol. Sci.

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Fukawa Takeshi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• Hirayama Ryoichi

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Hirayama Ryoichi

  Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.

• Uzawa Akiko

  京都大学原子炉実験所附属粒子線腫瘍学研究センター

• Sasai Keisuke

  Department Of Radilogy And Nuclear Medicine Faculty Of Medicine Kyoto University

• Furusawa Y

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Furusawa Yoshiya

  高エネルギー加速器研究機構物質構造科学研究所

• Fukawa Takeshi

  放射線医学総合研究所

• Kasai Soko

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kasai Soko

  Department Of Biological Science And Technology Faculty Of Engineering University Of Tokushima

• Aoki Mizuho

  Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.

• Koike Sachiko

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Takai Nobuhiko

  Department Of Molecular And Cellular Pharmacology Nagoya City University

• Hirayama Ryoichi

  Grad. Sch. Sci. Tech. Chiba Univ.

• Furusawa Yoshiya

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Ando Koichi

  Heavy-ion Radio. Res. Nirs

• Ando Koichi

  International Space Radiation Laboratory National Institute Of Radiological Sciences

• Furusawa Yoshiya

  Div. Of Accelerator Res. Natl. Inst. Of Radiol. Sci.

• Furusawa Yoshiya

  Heavy-ion Radiobiol. Res. Gr. Res. Center Charged Particle Therapy Nirs.

• Fukawa Takeshi

  慶応義塾大学

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