Protective Effects of Melatonin Against Low- and High-LET Irradiation

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• To investigate the protective effects of melatonin against high-LET ionizing radiation, V79 Chinese hamster cells were irradiated with 100 keV/μm carbon beam. Parallel experiments were performed with 200 kV X-rays. To avoid the impact from extra solvents, melatonin was dissolved directly in culture medium. Cells were cultured in melatonin medium for 1 hr before irradiation. Cell inactivation was measured with conventional colony forming assay, medium containing 6-thioguanine was used for the selection of mutants at hprt locus, and the cell cycle was monitored by flow cytometry. Both carbon beam and X-rays induced cell inactivation, hprt gene mutation and cell cycle G2 block dose-dependently. But carbon beam showed stronger effects as indicated by all three endpoints and the relative biological effectiveness (RBE) was 3.5 for cell killing (at 10% survival level) and 2.9 for mutation induction (at 5×10^<-5> mutants/cell level). Melatonin showed protective effects against ionizing radiation in a dose-dependent manner. In terms of cell killing, melatonin only increased the survival level of those samples exposed to 8Gy or larger of X-rays or 6 Gy or larger of carbon beam. In the induction of hprt mutation and G2 block, melatonin reduced such effects induced by carbon beam but not by X-rays. The results suggest that melatonin reduces the direct interaction of particles with cells rather than an indirect interaction. Further studies are required to disclose the underlying mechanisms.

• 日本放射線影響学会の論文
• 2006-06-30

著者

• 安藤 興一

  放医研

• Inoue Hiroko

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Ito Hisao

  Department Of Radiology Graduate School Of Medicine Chiba University

• FURUSAWA Yoshiya

  Heavy-ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• 安藤 興一

  学振科技特

• 安藤 興一

  Natl. Instit. Rad. Sci. Med.

• KAWATA Tetsuya

  Department of Radiology, Graduate School of Medicine, Chiba University

• FURUSAWA Yoshiya

  National Institute of Radiological Sciences

• FUTAMI Yasuyuki

  Shizuoka Cancer Center

• Futami Yasuyuki

  茨城県立医療大学 放射線技術科学科

• Futami Yasuyuki

  The Institute Of Physics University Of Tsukuba

• Futami Yasuyuki

  Dvisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Japa

• Ando Koichi

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• HIRAYAMA Ryoichi

  Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Instit

• Ando K

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Ando Koichi

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Aoki M

  Heavy-ion Radiobiology Research Group National Institute Of Radiological Sciences

• ZHOU Guangming

  Radiobiology Group, Institute of Modern Physics, Chinese Academy of Sciences

• AOKI Mizuho

  Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences

• Ando Soichiro

  National Institute Of Radiological Sciences

• Ando Koichi

  Department Of Technical Support And Development Natl. Inst. Radiol. Sci.

• Ando Koichi

  Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences

• Ando Koichi

  Division Of Health Sciences Graduate School Of Medicine Osaka University

• Hirayama Ryoichi

  Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut

• Hirayama Ryoichi

  Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.

• Zhou Guangming

  Radiobiology Group Institute Of Modern Physics Chinese Academy Of Sciences

• Furusawa Y

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Furusawa Yoshiya

  高エネルギー加速器研究機構物質構造科学研究所

• Aoki Mizuho

  Heavy-ion Radiobiol. Res. Gr. Natl. Inst. Radiol. Sci.

• Kawata Tetsuya

  Department Of Radiology Graduate School Of Medicine Chiba University

• Kawata Tetsuya

  Department Of Internal Medicine Ii Hokkaido University School Of Medicine

• Hirayama Ryoichi

  Grad. Sch. Sci. Tech. Chiba Univ.

• Furusawa Yoshiya

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Ito Hisao

  Department Of Radiology Chiba University School Of Medicine

• Ando Koichi

  Heavy-ion Radio. Res. Nirs

• Ito Hisao

  Department Of Radiology Chiba University Hospital

• Ando Koichi

  International Space Radiation Laboratory National Institute Of Radiological Sciences

• Ito Hisao

  Department Of Diagnostic Radiology And Respiratology Miyagi Prefectural Semine Hospital

• Furusawa Yoshiya

  Div. Of Accelerator Res. Natl. Inst. Of Radiol. Sci.

• Furusawa Yoshiya

  Heavy-ion Radiobiol. Res. Gr. Res. Center Charged Particle Therapy Nirs.

• Ito Hisao

  Departmen Of Radiology School Of Medicine Keio University

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