Glycine Betaine, a Beer Component, Protects Radiation-induced Injury
スポンサーリンク
概要
- 論文の詳細を見る
Human whole-blood was exposed to ^<137>Cs γ-rays or 50keV/μm carbon ions in the presence or absence of glycine betaine, a beer component in vitro. The dicentrics of chromosome aberrations in human lymphocytes were significantly (p<0.05) reduced by glycine betaine after irradiation with 4 Gy of either γ-rays or carbon ions. The maximum protection by glycine betaine for γ-rays or carbon ions was 37% and 20%, respectively. C3H/He female mice, aged 14weeks, received an i.p. injection of glycine betaine 15min before whole-body irradiation with γ-rays or 50keV/μm carbon ions. Glycine betaine significantly (p<0.05) increased the percent survival of irradiated mice with either γ-rays or carbon ions. In conclusion, glycine betaine is a potent protector against damages caused by low- and high-LET radiation.
- 日本放射線影響学会の論文
- 2005-03-25
著者
-
安藤 興一
放医研
-
安藤 興一
学振科技特
-
Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
-
安藤 興一
Natl. Instit. Rad. Sci. Med.
-
Ando K
Division Of Health Sciences Graduate School Of Medicine Osaka University
-
Ando Koichi
Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences
-
Monobe Manami
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
-
Monobe M
Chiba Univ. Chiba Jpn
-
Uzawa Akiko
Heavy-ion Radiobiology Research Group Research Center For Charged Particle Therapy National Institut
-
Ando Soichiro
National Institute Of Radiological Sciences
-
Ando Koichi
Department Of Technical Support And Development Natl. Inst. Radiol. Sci.
-
Ando Koichi
Space And Particle Radiation Science Research Group National Institute Of Radiological Sciences
-
Monobe Manami
Tokyo Univ. Sci. Chiba Japan
-
UZAWA Akiko
Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences
-
HINO Makiko
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science
-
ANDO Koichi
Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences
-
Ando Koichi
Division Of Health Sciences Graduate School Of Medicine Osaka University
-
Uzawa Akiko
京都大学原子炉実験所附属粒子線腫瘍学研究センター
-
Hino Makiko
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
-
Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
-
Ando Koichi
International Space Radiation Laboratory National Institute Of Radiological Sciences
関連論文
- 382 ATCCS (Adhesive Tumor Cell Culture System) 法を用いた消化器癌の放射線感受性試験の検討(第41回日本消化器外科学会総会)
- Chromosome Breakage and Cell Lethality in Human Hepatoma Cells Irradiated with X rays and Carbon-ion Beams
- Low-Dose Gamma-Ray Irradiation Induces Translocation of Nrf2 Into Nuclear in Mouse Macrophage RAW264.7 Cells
- 宇宙放射線類似線源による細胞がん化と(ヒト-ハムスター)ハイブリッド細胞を用いた逆線量率効果の解析
- Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography
- 25.骨肉腫の放射線治療効果に関する研究第1報 : マウス実験骨肉腫におけるγ線および速中性子線の効果(第738回千葉医学会整形外科例会)
- Reversed dose-rate effect of high LET radiation in mutation induction
- 156 Radiation protective effect of melatonin on mice(Radio-protection and sensitization, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 重粒子炭素線生物効果における時間因子と治療効果比
- 23.骨軟部悪性腫瘍に対する重粒子線治療の展望(第853回 千葉医学会整形外科例会)
- Development of a Radio-sensitive Mutation System for the Study of Dose Rate Effects of Space High LET Radiation
- 343 放射線治療における腫瘍血管および酸素分圧分布の影響
- Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo
- Evaluation of Late Radiation Damage of Normal Tissues in Mouse Hind Legs after Irradiation with Carbon Beams
- Time Dependent Reduction of Skin Shrinkage in Mouse after Irradiation with the Falloff of Carbon Bragg Peak
- HIMAC炭素イオンビーム照射によるヒト正常細胞の細胞死におけるLET依存性
- 重粒子線で誘発されるクロマチン切断誘発のLET依存性
- ネオンイオンビームによる細胞死と突然変異誘発効果
- Changes in the Pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation : Comparison with γ-Ray Radiation
- 22.C3Hマウス正常組織及び線維肉腫(NSFa)に対するEtoposideの腹腔内投与と放射線による修飾効果(第787回千葉医学会例会・第4回磯野外科例会)
- Protective Effects of Melatonin Against Low- and High-LET Irradiation
- Repair of Skin Damage During Fractionated Irradiation with Gamma Rays and Low-LET Carbon Ions
- Biological Gain of Carbon-ion Radiotherapy for the Early Response of Tumor Growth Delay and against Early Response of Skin Reaction in Mice
- 269 Significance of beta term in carbon-ion radiotherapy(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 265 Relationship between RBE values of Carbon Ion and Tumor Growth Rate(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 258 Different Responses of Malignant Melanomas and Squamous Cell Carcinomas to X-rays and Heavy-ion Beams-II(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Radioprotective Effects of Beer on Radiation-Induced Acute Toxicity in Mice
- Dependence of Gut-crypt Sensitivity on the Time Interval between Two Fractions of Carbon Ion Radiation
- Tumor Growth Rate and RBE values of high LET Carbon Ions
- Dependence of Carbon-Ion RBE on Dose Size -Difference between Skin and Tumors
- Different Responses of Malignant Melanomas and Squamous Cell Carcinomas to X-rays and Heavy-ion Beams
- Relative Biological Effectiveness of 290 MeV/u Carbon Ions for the Growth Delay of a Radioresistant Murine Fibrosarcoma
- Synthesis and Evaluation of 4-Bromo-1-(3-[^F]fluoropropyl)-2-nitroimidazole with a Low Energy LUMO Orbital Designed as Brain Hypoxia-Targeting Imaging Agent
- RBE of Carbon Ions for Tumor Growth Delay
- Fractionated irradiation with carbon ions induced resistance in mouse gut crypt cells
- Relative Biological Effectiveness of the 235 MeV Proton Beams at the National Cancer Center Hospital East
- Effects of sequentially mixed LET on tumor growth delay
- Fractionated irradiation with carbon ions to gut intestinal crypt cells
- ビールは放射線から体を守る?
- Tumor Induction in Mice Locally Irradiated with Carbon Ions : A Retrospective Analysis
- Therapeutic Effects of Gyokuheifusan on NC/Nga Mouse Model of Allergic Dermatitis
- Tumor Vasculature and PO2 Distributions Depend on Implantation Site
- LET, cell cycle dependence for mutation induction and spectrum in HPRT locus
- Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect
- Mutation induction on normal human cells by split dose irradiation with carbon-ion beams
- Cell death on human cells by split dose irradiation with carbonion beams.
- Morphometric Evaluation of Late Normal Tissue Damage after Neon Beam Irradiation in Mouse Hind Legs
- RBE of Heavy Ions (proton, carbon,neon) for Acute Cell Death of Pancreatic Islet Cells of the Golden Hamster(Mesocricetus auratus)
- Effects of fractionated irradiation with carbon ions on the NFSa fibrosarcoma in mice
- Dependence on dose and particle species of chromosome aberrations and cell lethality in human cells.
- Glycine Betaine, a Beer Component, Protects Radiation-induced Injury
- Biological Intercomparison Using Gut Crypt Survivals for Proton and Carbon-Ion Beams
- Relationship between Aberration Yield and Mitotic Delay in Human Lymphocytes Exposed to 200 MeV/u Fe-ions or X-rays
- Analysis of Biological Radiation Effects for Heavy Charged Particles - What is the physical quantity to specify those radiation quality -
- Apoptosis Induction in the NFSa tumor after irradiation with carbon ions
- Early Growth of Experimental Lung Metastasis in Mouse
- Effects of hypoxic condition on the tumor apoptosis induced by γ irradiation
- Radiation Effects on Primary Cultures of Mouse Brain Cells
- Early effects of carbon ion beam on adult mouse brain tissues:damage to the hippocampus
- Heavy ions-induced cognitive dysfunction in the ddy mice
- Response of Mouse Intestine to Carbon-12 Beams in Relation to Dose Fraction and Effects of Steroids on Radiation-Induced Intestinal Damages
- Biological features of tissue response after fractionated irradiation with carbon ions
- Elevation of Antioxidant Enzymes in the Clinical Effects of Radon and Thermal Therapy for Bronchial Asthma
- Chromosomal aberrations in lymphocytes induced by esophageal cancer radiotherapy using PCC+FISH techniques
- The Proliferative Response of Mouse Intestinal Crypts during Fractionated Irradiation of Carbon Ion Beams and X-rays
- Diesel exhaust (DE) aggravates pathology of delayed-type hypersensitivity (DTH) Induced by methyl-bovine serum albumin (mBSA) in mice
- Expression of VEGF mRNA by irradiation with X-ray and heavy-ion beam
- The isoeffect dose of carbon ions depends on LET and fractionation
- Reoxygenation of artificially hypoxic tumors
- Suppressing Effect of Low-Dose Gamma-Ray Irradiation on Collagen-Induced Arthritis
- Effects of Beer Administration in Mice on Acute Toxicities Induced by X Rays and Carbon Ions
- Drinking Beer Reduces Radiation-induced Chromosome Aberrations in Human Lymphocytes
- 重粒子線の生物学 (特集 HIMAC:放射線医学最前線--重粒子によるがん治療)
- Differences in pO_2 Peaks of a Murine Fibrosarcoma between Carbon-ion and X-ray Irradiation
- 267 Early Change of ^C-Thymidine Uptake after Carbon-beam Irradiation in Experimental Tumors(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Enhancement of the relative uptake of F-FDG in mouse fibrosarcoma by rolipram
- Tumor induction in mouse legs after irradiation with heavy ions
- Repair Kinetics of DNA-DSB Induced by X-rays or Carbon Ions under Oxic and Hypoxic Conditions
- Chromosomal Aberrations in Lymphocytes of Lung Cancer Patients Treated with Carbon Ions
- Chromosomal aberrations in lung cancer patients' lymphocytes induced by heavy ion therapy using PCC+FISHtechniques
- Chromosomal aberrations in lymphocytes induced by fractionated irradiation with carbon ions
- Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells
- Ectopic Neurons in the Hippocampus may be a Cause of Learning Disability after Prenatal Exposure to X-rays in Rats
- 198 LET dependence of Oxidative DNA Damage Induced by Heavy Ions under Hypoxic Condition(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Low Dose γ-Rays Activate Immune Functions via Induction of Glutathione and Delay Tumor Growth
- Long-term Memory and Neuropathological Effects of Prenatal X-irradiation in the Rat
- Recovery of clonogenic tumor cells after irradiation with carbon ions
- De-coupling of blood flow and metabolism in the rat brain induced by glutamate
- Role of NMDA receptor upon [^C]acetate uptake into intact rat brain
- Mouse leg contracture after irradiation with 290 MeV/u C-12 SOBP.
- Mouse Skin Shrinkage after Fractionated Irradiation with Carbon-12 beam
- Immunomodulatory Effects of Gyokuheifusan on INF-γ/IL-4 (Th1/Th2) Balance in Ovalbumin (OVA)-Induced Asthma Model Mice(Pharmacology)
- Paralysis of rats after spinal cord irradiation with carbon ions
- Induction of Thymic Lymphomas by Carbon Ions
- Effect of Repeated Small-Dose γ-Ray Irradiation on Atopic Dermatitis in NC/Nga Mice
- Repeated Irradiations with γ-rays at a Dose of 0.5 Gy May Exacerbate Asthma
- Change of Estrogenic Activity and Release of Chloride Ion in Chlorinated Bisphenol A after Exposure to Ultraviolet B(Analytical Biochemistry)
- Enhancement of X-ray-induced apoptosis by lonidamine
- Kinetics of Lung Metastasis between initial lodgement and Growth
- Involvement of P2Y receptors in the protective effect of ATP towards the cell damage in HaCaT cells exposed to H_2O_2