Repeated Irradiations with γ-rays at a Dose of 0.5 Gy May Exacerbate Asthma
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概要
- 論文の詳細を見る
We previously showed that 0.5 Gy whole-body γ-ray irradiation with a single or small number of repeated exposures inhibits tumor growth in mice, via elevation of the IFN-γ/IL-4 ratio concomitantly with a decrease in the percentage of B cells. Here we examined whether repeated 0.5 Gy γ-rays irradiation can improve asthma in an OVA-induced asthmatic mouse model. We found that repeated irradiation (10 times) with 0.5 Gy of γ-rays significantly increased total IgE in comparison with the disease-control group. The levels of IL-4 and IL-5 were also significantly higher in the γ-ray-irradiated group, while that of IFN-γ was significantly lower, resulting in a further decrease of the IFN-γ/IL-4 ratio from the normal value. These results indicate that the repeated irradiation with γ-rays may exacerbate asthma, and may have opposite effects on different immune reactions unlike the irradiation with a single or small number of repeated exposures.
- 日本放射線影響学会の論文
- 2005-06-30
著者
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TANAKA Takashi
Department of Physics, Faculty of Science, Okayama University
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Kojima Shuji
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kojima Shuji
岡山大学 医学部
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Fang Su
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Tago Fumitoshi
Department of Radiation Biosciences, Faculty of Pharmaceutical Science, Tokyo University of Science
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Tago Fumitoshi
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Muto Yasuko
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Fang Su-ping
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Simura Noriko
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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MUTO Yasuko
Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, Universi
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GOTO Resuke
Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, Universi
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Tanaka Takashi
Department Of Internal Medicine Fukui Cardiovascular Center
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Goto Resuke
Laboratory Of Radiation Biology Graduate School Of Nutritional And Environmental Sciences University
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Simura Noriko
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Tanaka Takashi
Department Of Central Clinical Laboratory Teikyo University Hospital
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