Effect of Heterocyclic Pyrimidine Compounds on UVB-Induced Cell Damage in Human Keratinocytes and on Melanogenesis in Mouse B16 Cells
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概要
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We investigated the protective effect of several heterocyclic pyrimidine compounds against ultraviolet B (UVB)-induced damage in human keratinocyte HaCaT cells, as well as the inhibitory effect on melanogenesis in B16 melanoma cells. One of the compounds examined, 2-piperadino-6-methyl-5-oxo-5,6-dihydro(7H)pyrrolo[3,4d]pyrimidine maleate (MS-818), showed low cytotoxicity even at 500 μM. At 50—500 μM, MS-818 dose-dependently suppressed the UVB (100 mJ/cm2)-induced elevation of tumor necrosis factor alpha (TNF-α), one of the trigger cytokines for cell death, in HaCaT cells. In addition, MS-818 (100 μM) markedly inhibited melanogenesis in B16 melanoma cells via downregulation of tyrosinase expression mediated by microphthalmia-associated transcription factor (MITF) and extracellular signal-regulated kinase (ERK). In conclusion, MS-818 protected epidermal cells from UVB-induced damage and also suppressed melanogenesis in melanoma cells. It appears to be a good candidate for a new UVB-protective and whitening agent for application in cosmetics.
著者
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Shimoda Nao
Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS)
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Mutou Yasuko
Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS)
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Shimura Noriko
Faculty of Pharmaceutical Sciences, Ohu University
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Tsukimoto Mitsutoshi
Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS)
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Awaya Akira
Dermatology and Epidemiology Research Institute
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Kojima Shuji
Faculty of Pharmaceutical Sciences, Tokyo University of Science (TUS)
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Kojima Shuji
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Tsukimoto Mitsutoshi
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Awaya Akira
Dermatology And Epidemiology Res. Inst.
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Mutou Yasuko
Laboratory Of Radiation Biology Graduate School Of Nutritional And Environmental Sciences University
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