Elevation of Antioxidant Enzymes in the Clinical Effects of Radon and Thermal Therapy for Bronchial Asthma
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概要
- 論文の詳細を見る
An increased systemic production of oxygen-free radicals by activated inflammatory cells is thought to be involved in the pathophysiology of asthma. The aim of this study is to evaluate the clinical effects of radon and thermal therapy on asthma in relation to antioxidant enzymes and lipid peroxide. Radon and thermal therapy were performed once a week. All subjects went to a hot bathroom with a high concentration of radon, and nasal inhalation of vapor from a hot spring was performed for 40 min once a day under conditions of high humidity. The room temperature was 48℃; the room radon concentration was 2,080 Bq/m^3. Blood samples were collected at 2 h, 14, and 28 days after the first therapy. A blood sample also was collected before the first therapy (at body temperature and background radon level) to be used as the control. The forced expiratory volume in one second (%FEV_1) was significantly increased 28 days after the first therapy. On day 28, the catalase (CAT) activity was significantly increased in comparison with the control. The superoxide dismutase (SOD) activity was significantly increased compared to the control after first inhalation. On days 14 and 28, the lipid peroxide level was significantly decreased in comparison with the control. In conclusion, the present pilot study has shown that radon and thermal therapy improved the pulmonary function of asthmatics by increasing the reduced activities of antioxidant enzymes.
- 日本放射線影響学会の論文
著者
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Shibuya Koichi
Chair Of Medical Radioscience
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Shibuya Koichi
岡山大学 医学部放射線医学
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Kojima Shuji
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Sakai Kazuo
Resarch Center For Radiation Protection National Institute Of Radiological Sciences
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YAMAOKA Kiyonori
Departments of Radiological Technology, Okayama University Medical School
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HANAMOTO Katsumi
Departments of Radiological Technology, Okayama University Medical School
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TANIZAKI Yoshiro
Misasa Medical Center, Okayama University Medical School
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MITSUNOBU FUMIHIRO
Department of Medicine, Misasa Medical Center, Okayama University Medical School
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HOSAKI YASUHIRO
Department of Medicine, Misasa Medical Center, Okayama University Medical School
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ASHIDA KOZO
Department of Medicine, Misasa Medical Center, Okayama University Medical School
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SUGITA KATSUHIRO
Department of Radiological Technology, Okayama University Medical School
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TANIZAKI YOSHIRO
Department of Medicine, Misasa Medical Center, Okayama University Medical School
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Hosaki Yasuhiro
Department Of Medicine Misasa Medical Center Okayama University Medical School
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Sakai Kazuo
電中研原子力技術研究所 放射線安全研究センター
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Ashida Kozo
Department Of Medicine Misasa Medical Center Okayama University Medical School
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Kira S
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Mitsunobu Fumihiro
Misasa Medical Center Okayama University Hospital
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Mitsunobu Fumihiro
Department Of Biochemistry Cancer Institute Okayama University Medical School
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YAMAOKA Kiyonori
Graduate School of Health Sciences, Okayama University
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HANAMOTO Katsumi
Graduate School of Health Sciences, Okayama University
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Sugita Katsuhiro
Chair Of Medical Radioscience
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Hanamoto Katsumi
Graduate School Of Health Sciences Okayama University
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Tanizaki Y
Misasa Medical Center Okayama University Medical School
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Yamaoka Kiyonori
Graduate School Of Health Sciences Okayama University
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Yamaoka Kiyonori
Department of Radiological Technology, Graduate School of Health Sciences, Okayama University
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