Immunomodulatory Effects of Gyokuheifusan on INF-γ/IL-4 (Th1/Th2) Balance in Ovalbumin (OVA)-Induced Asthma Model Mice(Pharmacology)
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概要
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Asthma, a common, chronic lung disease in industrialized countries, is characterized by the production of large quantities of IgE antibody by B cells and a decrease of the IFN-γ/IL-4 (Th1/Th2) ratio. Gyokuheifusan (GHS) is a classical formulation of traditional Chinese medicine (TCM) that is usually prescribed to prevent or treat respiratory tract diseases, such as respiratory infection and bronchial asthma. In order to evaluate the possible effectiveness of GHS on bronchial asthma, its immunomodulatory activity was examined in ovalbumin (OVA)-induced asthma model mice. All mice, except those in the normal group, were sensitized by intraperitoneal (IP) administration of OVA emulsified with Al(OH)_3, and a second immunization was given 6d later. After a further 13, 17 and 21d, mice were challenged with inhalation of aerosolized OVA solution, except for the normal group, which received mock sensitization using saline-Al(OH)_3 emulsion and were challenged with an aerosol of saline without OVA. Allergen-specific IgE and total IgE in plasma were both significantly increased in the disease-control group. These increases were markedly blocked by GHS treatment. IFN-γ released by splenocytes was significantly increased after co-culture with OVA for 24h, 48h, and 72h. GHS treatment further elevated the IFN-γ content compared with the disease-control group. The production of IL-4 was significantly increased when splenocytes were simulated with OVA for 72h, but this increase was blocked by GHS treatment, so that GHS returned the decreased IFN-γ/IL-4 (Th1/Th2) ratio of the disease-control group to the normal range. These results indicate that GHS may inhibit the development and severity of asthma.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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OKAMOTO Takuya
Iskra Industry Co., Ltd.
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Fang Su
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Tanaka Takeshi
Department Of Cardiology The Heart Institute Of Japan
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Okamoto T
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy:iskura Industry Co. Ltd.
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Okamoto Takuya
Iskura Industry Co. Ltd.
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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TAGO Fumitosi
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Tago Fumitosi
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Fang Su-ping
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Kojima Shuji
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (
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Tanaka Takeshi
Department Of Biomedical Chemistry Graduate School Of Medicine The University Of Tokyo
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Tanaka Takeshi
Department Of Radiation Biosciences Faculty Of Pharmaceutical Sciences Tokyo University Of Science (rikadai)
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岡本 拓也
摂南大学薬学部薬品物性化学研究室
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