Effects of Kangen-karyu on Coagulation System and Platelet Aggregation in Mice
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概要
- 論文の詳細を見る
Kangen-karyu (KGK) is a herbal formula created under the theory of traditional Chinese herbal medicine to invigorate the blood and dispel blood stasis. It contains 6 herbs: peony root, cnidium rhizome, safflower, cyperus rhizome, saussurea root (JP XIV), and Salvia miltiorrhiza root. The present study has been conducted to evaluate the in vivo anti-thrombotic activity of KGK using normal mice. Three consecutive days of oral administration of KGK to mice significantly extended tail-bleeding time and suppressed ex vivo platelet aggregation, while it did not extend the prothrombin time of plasma. It was revealed that the anti-thrombotic effects of KGK did not depend on the downregulation of the coagulation system, but depended in part on the inhibition of platelet aggregation. These results explain one of the pharmacological activities of KGK to invigorate the blood and dispel blood stasis.
- 社団法人日本薬学会の論文
- 2002-04-01
著者
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OKAMOTO Takuya
Iskra Industry Co., Ltd.
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Katagiri Yoshihlro
Hokkaido Institute Of Pharmaceutical Sciences
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Okamoto T
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy:iskura Industry Co. Ltd.
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MAKINO Toshiaki
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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WAKUSHIMA Hannosuke
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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OKAMOTO Takuya
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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OKUKUBO Yasuhiro
Iskura Industry Co., Ltd.
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Okamoto Takuya
Department Of Communications And Computer Engineering Graduate School Of Informatics Kyoto Universit
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
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Makino Toshiaki
R&d Division Sunstar Inc.
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Makino T
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sci. Nagoya City Univ.
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Makino Toshiaki
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Sasaki Kanako
Riken Kanagawa Jpn
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Okukubo Yasuhiro
Iskura Industry Co. Ltd.
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Wakushima Hannosuke
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Makino Toshiaki
Department Of Chemistry Faculty Of Science Okayam University Of Science
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Makino Taketoshi
R&d Center Sunstar Inc.
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Makino Toshiaki
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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岡本 拓也
摂南大学薬学部薬品物性化学研究室
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