Simplified Procedures for the Simultaneous Determination of Enoxacin, Fenbufen and Felbinac in Rat Plasma by High-performance Liquid Chromatography
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概要
- 論文の詳細を見る
A high-performance liquid chromatography has been employed for a simplified simultaneous, determination of enoxacin, fenbufen and its active metabolite, felbinac, in rat plasma. Enoxacin, fenbufen and felbinac were simultaneously extracted from 50μl of rat plasma and analyzed by using liquid chromatography equipped with a reversed-phase column. By the present method, reproducible quantitative determinations were possible for enoxacin, fenbufen and felbinac over the concentration range of 0.2-20, 0.2-120 and 0.4-40 μg/ml, respectively. The recovery of enoxacin, fenbufen and felbinac added to plasma was 93% to nearly 100% with the coefficient of variation less than 3.0%. This method is applicable to the detailed pharmacokinetic studies of each drug after a concomitant administration of enoxacin and fenbufen.
- 日本医療薬学会の論文
- 1989-08-20
著者
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ICHIKAWA Nobuhiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Ichikawa N
Department Of Pharmacy Shimane Medical University Hospital
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Ichikawa Nobuhiro
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Ichikawa Nobuhiro
島根医科大学附属病院 薬剤
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Katagiri Yoshihlro
Hokkaido Institute Of Pharmaceutical Sciences
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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NAORA KOHJI
Department of Pharmacy, Shimane Medical University Hospital
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IWAMOTO KIKUO
Department of Pharmacy, Shimane Medical University Hospital
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HAYASHIBARA MASAKAZU
Department of Pharmacy, Tottori University Hospital
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KATAGIRI YOSHIHlRO
Department of Pharmacy, Shimane Medical University Hospital
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Naora K
Department Of Pharmacy Shimane University Hospital
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Naora Kohji
Department Of Pharmacy Shimane Medical University Hospital
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Iwamoto Kikuo
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Nagoya City University:(present Ad
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Iwamoto K
Department Of Pharmacy Shimane University Hospital
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Iwamoto Kikuo
Department Of Pharmacy Shimane University Hospital
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Hayashibara M
Department Of Hospital Pharmacy Tottori University School Of Medicine
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Katagiri Yoshihlro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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HAYASHIBARA MASAKAZU
Department of Hospital Pharmacy, Tottori University School of Medicine
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