High-Performance Liquid Chromatographic Assay of Clonazepam in Human Plasma Using a Non-porous Silica Column(Analytical Biochemistry)
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概要
- 論文の詳細を見る
A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 /Xm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5-200 ng/ml. The recoveries of CZP added to plasma were more than 94.0%, with a coefficient of variation in the range of 5.1-13.8%. We developed a rapid routine method using a non-porous silica column that was accurate and improved solvent consumption in the measurement of CZP.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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KATAGIRI Yoshihiro
Department of Pharmacy, Gifu University Hospital
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SUGIYAMA Tadashi
Department of Pharmacy, Gifu University Hospital
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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NAKAMURA Mitsuhiro
Department of Applied Physics and Chemistry, The University of Electro-Communications
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Sugiyama T
Division Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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FUKAWA Kana
Department of Pharmacy, Gifu University Hospital
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Fukawa K
Department Of Pharmacy Gifu University Hospital
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Semba T
Department Of Pharmacy Gifu University Hospital
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Katagiri Yoshihiro
Department Of Biochemistry Gifu Pharmaceutical University
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Nakamura Mitsuhiro
Department Of Pharmacy Gifu University Hospital
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Sugiyama Tadashi
Department Of Applied Chemistry Faculty Of Science Tokyo University Of Science
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Nakamura Mitsuhiro
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Katagiri Yoshihiro
Deparhnent of Pharmacy Gifu University Hospital
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